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      Lithium-Induced Downbeat Nystagmus and Horizontal Gaze Palsy

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          Abstract

          We report a case of lithium-induced downbeat nystagmus and horizontal gaze palsy in a 62-year-old woman who was treated for a bipolar affective disorder with lithium carbonate for one month. At presentation serum lithium was within therapeutic range. No alternative causes of the ocular motility disturbances were found, and the patient improved significantly as lithium carbonate was discontinued.

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          Eye movement disorders in vitamin B12 deficiency: two new cases and a review of the literature.

          G Akdal, G G Yener, A ADA … (2007)
          Eye movement disorders are rarely reported in vitamin B12 deficiency. We describe two cases with eye movement disorder and vitamin B12 deficiency; one with bilateral internuclear ophthalmoplegia and the other with downbeat nystagmus. Both of the patients received replacement therapy but their eye movement disorders did not respond to treatment. We also review the nine previously reported cases.
          Article 0 comments Cited 11 times – based on 0 reviews     Review now
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            Lithium-Induced Downbeat Nystagmus

            Irma Lessell, G. Michael Halmagyi, Ian Curthoys … (1989)
            Article 0 comments Cited 11 times – based on 0 reviews     Review now
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              Downbeating nystagmus and other ocular motor defects caused by lithium toxicity.

              J J Corbett, D Jacobson, H Thompson … (1989)
              We report the clinical and neuropathologic findings of a 63-year-old woman who died following an accidental lithium overdose that produced coma, respiratory depression, horizontal gaze palsy, and downbeating nystagmus. She also had mild hypomagnesemia. The pathology was cytotoxicity, predominantly in the regions of the nuclei prepositus hypoglossi and medial vestibular nucleus. Damage to this area with kainate and ibotenate in rhesus monkeys has produced horizontal gaze palsy and downbeating nystagmus. In addition, we report our clinical experience during the past 6 years with other examples of downbeating nystagmus in patients receiving lithium.
              Article 0 comments Cited 10 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Open Ophthalmol J
                Journal ID (iso-abbrev): Open Ophthalmol J
                Journal ID (publisher-id): TOOPHTJ
                Title: The Open Ophthalmology Journal
                Publisher: Bentham Open
                ISSN (Electronic): 1874-3641
                Publication date (Electronic): 29 April 2016
                Publication date Collection: 2016
                Volume: 10
                Pages: 126-128
                Affiliations
                [1 ]Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen, Denmark
                [2 ]Department of Neurology, Neuroscience Center, Rigshospitalet-Glostrup, Copenhagen, Denmark
                Author notes
                [* ]Address correspondence to this author at the Department of Ophthalmology Rigshospitalet-Glostrup Nordre Ringvej 57 2600 Glostrup; Denmark; Tel: +455133788; E-mail: jskovlund@ 123456hotmail.com
                Article
                Publisher ID: TOOPHTJ-10-126
                DOI: 10.2174/1874364101610010126
                PMC ID: 4899508
                PubMed ID: 27347248
                SO-VID: 266d3588-30b7-4e2c-933a-05e4bdca64c8
                Copyright © © Jørgensen et al.; Licensee Bentham Open.
                License:

                This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

                History
                Date received : 3 November 2015
                Date revision received : 17 January 2016
                Date accepted : 25 January 2016
                Categories
                Subject: Article

                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: adverse effects,downbeat nystagmus,gaze palsy,lithium
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: adverse effects, downbeat nystagmus, gaze palsy, lithium

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