Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene (ACE) and the C825T polymorphism in the G-protein β3 subunit gene (GNB3) are associated with the efficacy of phosphodiesterase-5 inhibitor (PDE-5I) in erectile dysfunction. In addition, GNB3 genotypes could be associated with clinical worsening in pulmonary hypertension (PH) treated with PDE-5I. However, no studies have described the synergistic effects of gene polymorphisms on drug efficacy in patients with PH.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Respiration

Title: Respiration; international review of thoracic diseases

Publisher: S. Karger AG

ISSN (Electronic): 1423-0356

ISSN (Print): 0025-7931

Publication date (Electronic): 2016

Volume: 91

Issue: 2

Affiliations

[1 ] Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Article

Publisher Item ID: 000443772

DOI: 10.1159/000443772

PubMed ID: 26821322

SO-VID: 266405fb-b9d5-4f67-9452-2a7739f51eb4

History

Data availability:

Comments

Comment on this article

scite_

Cited by 3

See all cited by