- Record: found
- Abstract: found
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Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
review-article
29 December 2014
Lipid peroxidation,
4-HNE,
Mitochondria,
Cancer,
Free radicals,
Cardiolipin,
4-HNE, 4-hydroxy-2-alkenals,
4-ONE, 4-oxo-2-nonenal,
8-oxo-dG, 8-oxoguanine,
AA, arachidonic acid,
ADH, alcohol dehydrogenases,
AKRs, aldo-keto reductases,
ALDH, aldehyde dehydrogenases,
ALDH2, aldehyde dehydrogenase 2 family(mitochondrial),
As2O3, arsenic trioxide,
ATP5B, ATP synthase subunit β,
CL, cardiolipin,
DHA, docosahexaenoic acid,
DHN, 1,4-dihydroxy-2-nonene,
DOX, doxorubicin,
EAA-CL, epoxyalcohol-aldehyde-cardiolipin,
ETC, electron transport chain,
FapyA, 4,6-diamino-5-formamidopyrimidine,
FapyG, 2,6-diamino-4-hydroxy-5-formamidopyrimidine,
GSH, glutathione,
GS-HNE, glutathionyl-HNE,
GSTs, glutathione-S-transferases,
HADHA, trifunctional enzyme subunit α,
HNA, 4-hydroxy-2-nonenoic acid,
HODE, hydroxyoctadecadienoic acid,
HpODE, hydroperoxyoctadecadienoic acid,
IMM, inner membrane of mitochondria,
KODE, keto-octadecadienoic acid,
L4CL, tetralinoleoyl cardiolipin,
LA, linoleic acid,
LPO, lipid peroxidation,
mtDNA, mitochondrial DNA,
NDUFS2, NADH dehydrogenase [ubiquinone] iron–sulfur protein 2,
OMM, outer membrane of mitochondria,
PC, phosphatidylcholine,
PE, phosphatidylethanolamine,
PS, phosphatidylserine,
PUFAs, polyunsaturated fatty acids,
ROS, reactive oxygen species,
SDHA, succinate dehydrogenase [ubiquinone] flavoprotein subunit,
UADT, upper aero digestive track,
UCPs, mitochondrial uncoupling proteins
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Abstract
Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.
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Most cited references51
- Record: found
- Abstract: found
- Article: not found
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
Cynthia Gay, L. Ritland, Antonio F Santidrián … (2013)
- Record: found
- Abstract: found
- Article: not found
4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest.
W Siems, R Schaur, G Leonarduzzi … (2008)
Author and article information
lipid peroxidation,4-hne,mitochondria,cancer,free radicals,cardiolipin,4-hne, 4-hydroxy-2-alkenals,4-one, 4-oxo-2-nonenal,8-oxo-dg, 8-oxoguanine,aa, arachidonic acid,adh, alcohol dehydrogenases,akrs, aldo-keto reductases,aldh, aldehyde dehydrogenases,aldh2, aldehyde dehydrogenase 2 family(mitochondrial),as2o3, arsenic trioxide,atp5b, atp synthase subunit β,cl, cardiolipin,dha, docosahexaenoic acid,dhn, 1,4-dihydroxy-2-nonene,dox, doxorubicin,eaa-cl, epoxyalcohol-aldehyde-cardiolipin,etc, electron transport chain,fapya, 4,6-diamino-5-formamidopyrimidine,fapyg, 2,6-diamino-4-hydroxy-5-formamidopyrimidine,gsh, glutathione,gs-hne, glutathionyl-hne,gsts, glutathione-s-transferases,hadha, trifunctional enzyme subunit α,hna, 4-hydroxy-2-nonenoic acid,hode, hydroxyoctadecadienoic acid,hpode, hydroperoxyoctadecadienoic acid,imm, inner membrane of mitochondria,kode, keto-octadecadienoic acid,l4cl, tetralinoleoyl cardiolipin,la, linoleic acid,lpo, lipid peroxidation,mtdna, mitochondrial dna,ndufs2, nadh dehydrogenase [ubiquinone] iron–sulfur protein 2,omm, outer membrane of mitochondria,pc, phosphatidylcholine,pe, phosphatidylethanolamine,ps, phosphatidylserine,pufas, polyunsaturated fatty acids,ros, reactive oxygen species,sdha, succinate dehydrogenase [ubiquinone] flavoprotein subunit,uadt, upper aero digestive track,ucps, mitochondrial uncoupling proteins
lipid peroxidation, 4-hne, mitochondria, cancer, free radicals, cardiolipin, 4-hne, 4-hydroxy-2-alkenals, 4-one, 4-oxo-2-nonenal, 8-oxo-dg, 8-oxoguanine, aa, arachidonic acid, adh, alcohol dehydrogenases, akrs, aldo-keto reductases, aldh, aldehyde dehydrogenases, aldh2, aldehyde dehydrogenase 2 family(mitochondrial), as2o3, arsenic trioxide, atp5b, atp synthase subunit β, cl, cardiolipin, dha, docosahexaenoic acid, dhn, 1,4-dihydroxy-2-nonene, dox, doxorubicin, eaa-cl, epoxyalcohol-aldehyde-cardiolipin, etc, electron transport chain, fapya, 4,6-diamino-5-formamidopyrimidine, fapyg, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, gsh, glutathione, gs-hne, glutathionyl-hne, gsts, glutathione-s-transferases, hadha, trifunctional enzyme subunit α, hna, 4-hydroxy-2-nonenoic acid, hode, hydroxyoctadecadienoic acid, hpode, hydroperoxyoctadecadienoic acid, imm, inner membrane of mitochondria, kode, keto-octadecadienoic acid, l4cl, tetralinoleoyl cardiolipin, la, linoleic acid, lpo, lipid peroxidation, mtdna, mitochondrial dna, ndufs2, nadh dehydrogenase [ubiquinone] iron–sulfur protein 2, omm, outer membrane of mitochondria, pc, phosphatidylcholine, pe, phosphatidylethanolamine, ps, phosphatidylserine, pufas, polyunsaturated fatty acids, ros, reactive oxygen species, sdha, succinate dehydrogenase [ubiquinone] flavoprotein subunit, uadt, upper aero digestive track, ucps, mitochondrial uncoupling proteins