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      Association of Suicide and Other Mortality With Emergency Department Presentation

      research-article
      , PhD 1 , , , MD, MPH 2 , , PhD 1 , , PhD 3
      JAMA Network Open
      American Medical Association

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          Abstract

          This cohort study examines the association of suicide and other mortality risk within 1 year of emergency department presentation among patients presenting with deliberate self-harm, suicidal ideation, or any other chief concern.

          Key Points

          Question

          Is emergency department presentation associated with 1-year incidence of suicide and other mortality, and does the suicide rate vary by patient clinical and sociodemographic characteristics?

          Findings

          In this cohort study including 648 646 patients who presented to California emergency departments, compared with the demographically matched general population, suicide mortality was 56.8-fold higher among patients presenting with deliberate self-harm, 31.4-fold higher among patients presenting with suicidal ideation, and 1.9-fold higher among patients presenting with any other chief concern; risk of other mortality was also increased. Sociodemographic and clinical factors associated with suicide risk varied by patient group.

          Meaning

          These findings suggest that broad implementation of suicide risk screening and intervention is needed in emergency department settings, and the scope of interventions should also consider suicidal individuals’ risk for unintentional injury and other premature mortality.

          Abstract

          Importance

          Emergency departments (EDs) have the potential to play a pivotal role in suicide risk detection and prevention, yet little is known about the profile of risk of suicide after ED visits in the United States.

          Objectives

          To examine 1-year incidence of suicide and other mortality among ED patients who presented with nonfatal deliberate self-harm, suicidal ideation, or any other chief concern, and to examine sociodemographic and clinical factors associated with suicide mortality risk.

          Design, Setting, and Participants

          This retrospective cohort study included statewide, all-payer, longitudinally linked ED patient records and mortality data from all California residents who presented to a California-licensed ED at least 1 time from January 1, 2009, to December 31, 2011, with deliberate self-harm, suicidal ideation but not self-harm, or neither (a 5% random sample). Age-, sex-, and race/ethnicity-adjusted standardized mortality ratios (SMRs) for suicide and other manners or causes of death were determined for each patient group using statewide mortality data. Data were analyzed from January 10 to July 18, 2019.

          Main Outcomes and Measures

          Suicide and other manners or causes of death were ascertained using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes. Suicide rate and all mortality rates were measured per 100 000 person-years.

          Results

          Among 648 646 individuals (mean [SD] age, 43.8 [20.6] years; 350 687 [54.1%] women) who visited an ED in California from 2009 to 2011, the rates of suicide deaths per 100 000 person-years in the year after index ED presentation were 693.4 deaths among 83 507 individuals presenting with deliberate self-harm (SMR, 56.8; 95% CI, 52.1-61.4), 384.5 deaths among 67 379 individuals presenting with suicidal ideation but not self-harm (SMR, 31.4; 95% CI, 27.5-35.2), and 23.4 deaths among 497 760 reference patients (SMR, 1.9; 95% CI, 1.6-2.3). Compared with the demographically matched general population, the rates of nonsuicide external-cause mortality were also increased among patients with self-harm (SMR, 14.2; 95% CI, 12.9-15.5), patients with suicidal ideation (SMR, 11.8; 95% CI, 10.6-13.0), and reference patients (SMR, 2.2; 95% CI, 2.0-2.3). In all 3 groups, the rates of suicide mortality per 100 000 person-years were higher among men (deliberate self-harm: 1011.1 deaths; suicidal ideation: 539.8 deaths; reference: 36.6 deaths), people 65 years or older (deliberate self-harm: 1919.5 deaths; suicidal ideation: 691.2 deaths; reference: 28.6 deaths), and non-Hispanic white patients (deliberate self-harm: 914.1 deaths; suicidal ideation: 511.6 deaths; reference: 33.8 deaths) than among their respective referent groups. Other sociodemographic factors and clinical diagnoses were associated with striking differences in suicide rates, but these patterns were heterogeneous across patient groups.

          Conclusions and Relevance

          These findings suggest that ED patients with deliberate self-harm or suicidal ideation are associated with substantially increased risk of suicide and other mortality during the year after ED presentation. The process of planning for ED discharge may present opportunities to help ensure safe transitions to continuing outpatient mental health care and to consider broader risk for unintentional injury and other causes of premature mortality.

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          Most cited references21

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          Self-injurious thoughts and behaviors as risk factors for future suicide ideation, attempts, and death: a meta-analysis of longitudinal studies.

          A history of self-injurious thoughts and behaviors (SITBs) is consistently cited as one of the strongest predictors of future suicidal behavior. However, stark discrepancies in the literature raise questions about the true magnitude of these associations. The objective of this study is to examine the magnitude and clinical utility of the associations between SITBs and subsequent suicide ideation, attempts, and death.
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            Does response on the PHQ-9 Depression Questionnaire predict subsequent suicide attempt or suicide death?

            OBJECTIVE As use of standard depression questionnaires in clinical practice increases, clinicians will frequently encounter patients reporting thoughts of death or suicide. This study examined whether responses to the Patient Health Questionnaire for depression (PHQ-9) predict subsequent suicide attempt or suicide death. METHODS Electronic records from a large integrated health system were used to link PHQ-9 responses from outpatient visits to subsequent suicide attempts and suicide deaths. A total of 84,418 outpatients age ≥13 completed 207,265 questionnaires between 2007 and 2011. Electronic medical records, insurance claims, and death certificate data documented 709 subsequent suicide attempts and 46 suicide deaths in this sample. RESULTS Cumulative risk of suicide attempt over one year increased from .4% among outpatients reporting thoughts of death or self-harm "not at all" to 4% among those reporting thoughts of death or self-harm "nearly every day." After adjustment for age, sex, treatment history, and overall depression severity, responses to item 9 of the PHQ-9 remained a strong predictor of suicide attempt. Cumulative risk of suicide death over one year increased from .03% among those reporting thoughts of death or self-harm ideation "not at all" to .3% among those reporting such thoughts "nearly every day." Response to item 9 remained a moderate predictor of subsequent suicide death after the same factor adjustments. CONCLUSIONS Response to item 9 of the PHQ-9 for depression identified outpatients at increased risk of suicide attempt or death. This excess risk emerged over several days and continued to grow for several months, indicating that suicidal ideation was an enduring vulnerability rather than a short-term crisis.
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              Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department

              Question Can a brief suicide prevention intervention reduce suicidal behaviors and improve treatment engagement among patients who present to the emergency department for suicide-related concerns? Findings In this cohort comparison study, patients who visited the emergency department for suicide-related concerns and received the Safety Planning Intervention with structured follow-up telephone contact were half as likely to exhibit suicidal behavior and more than twice as likely to attend mental health treatment during the 6-month follow-up period compared with their counterparts who received usual care following their ED visit. Meaning The Safety Planning Intervention with structured follow-up telephone contact may be an effective brief suicide prevention intervention that can be implemented in emergency departments. Importance Suicidal behavior is a major public health problem in the United States. The suicide rate has steadily increased over the past 2 decades; middle-aged men and military veterans are at particularly high risk. There is a dearth of empirically supported brief intervention strategies to address this problem in health care settings generally and particularly in emergency departments (EDs), where many suicidal patients present for care. Objective To determine whether the Safety Planning Intervention (SPI), administered in EDs with follow-up contact for suicidal patients, was associated with reduced suicidal behavior and improved outpatient treatment engagement in the 6 months following discharge, an established high-risk period. Design, Setting, and Participants Cohort comparison design with 6-month follow-up at 9 EDs (5 intervention sites and 4 control sites) in Veterans Health Administration hospital EDs. Patients were eligible for the study if they were 18 years or older, had an ED visit for a suicide-related concern, had inpatient hospitalization not clinically indicated, and were able to read English. Data were collected between 2010 and 2015; data were analyzed between 2016 and 2018. Interventions The intervention combines SPI and telephone follow-up. The SPI was defined as a brief clinical intervention that combined evidence-based strategies to reduce suicidal behavior through a prioritized list of coping skills and strategies. In telephone follow-up, patients were contacted at least 2 times to monitor suicide risk, review and revise the SPI, and support treatment engagement. Main Outcomes and Measures Suicidal behavior and behavioral health outpatient services extracted from medical records for 6 months following ED discharge. Results Of the 1640 total patients, 1186 were in the intervention group and 454 were in the comparison group. Patients in the intervention group had a mean (SD) age of 47.15 (14.89) years and 88.5% were men (n = 1050); patients in the comparison group had a mean (SD) age of 49.38 (14.47) years and 88.1% were men (n = 400). Patients in the SPI+ condition were less likely to engage in suicidal behavior (n = 36 of 1186; 3.03%) than those receiving usual care (n = 24 of 454; 5.29%) during the 6-month follow-up period. The SPI+ was associated with 45% fewer suicidal behaviors, approximately halving the odds of suicidal behavior over 6 months (odds ratio, 0.56; 95% CI, 0.33-0.95, P  = .03). Intervention patients had more than double the odds of attending at least 1 outpatient mental health visit (odds ratio, 2.06; 95% CI, 1.57-2.71; P  < .001). Conclusions and Relevance This large-scale cohort comparison study found that SPI+ was associated with a reduction in suicidal behavior and increased treatment engagement among suicidal patients following ED discharge and may be a valuable clinical tool in health care settings. This study examines whether a safety planning intervention, administered in emergency departments with follow-up contact for suicidal patients, was associated with subsequent suicidal behavior and outpatient treatment engagement in the 6 months following discharge.
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                Author and article information

                Journal
                JAMA Netw Open
                JAMA Netw Open
                JAMA Netw Open
                JAMA Network Open
                American Medical Association
                2574-3805
                13 December 2019
                December 2019
                13 December 2019
                : 2
                : 12
                : e1917571
                Affiliations
                [1 ]Department of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced
                [2 ]Department of Psychiatry, Columbia University, New York, New York
                [3 ]Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, Maryland
                Author notes
                Article Information
                Accepted for Publication: October 22, 2019.
                Published: December 13, 2019. doi:10.1001/jamanetworkopen.2019.17571
                Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2019 Goldman-Mellor S et al. JAMA Network Open.
                Corresponding Author: Sidra Goldman-Mellor, PhD, Department of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced, 5200 N Lake Rd, Merced, CA 95343 ( sgoldman-mellor@ 123456ucmerced.edu ).
                Author Contributions: Dr Goldman-Mellor had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
                Concept and design: Goldman-Mellor, Schoenbaum.
                Acquisition, analysis, or interpretation of data: All authors.
                Drafting of the manuscript: Goldman-Mellor, Schoenbaum.
                Critical revision of the manuscript for important intellectual content: All authors.
                Statistical analysis: Goldman-Mellor, Schoenbaum.
                Obtained funding: Goldman-Mellor.
                Supervision: Goldman-Mellor.
                Conflict of Interest Disclosures: None reported.
                Funding/Support: This study was funded through grant R15 MH113108-01 from the National Institutes of Health (Dr Goldman-Mellor).
                Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
                Disclaimer: The views expressed in this article are those of the authors and not necessarily those of the National Institute of Mental Health, Department of Health and Human Services, or the US federal government.
                Article
                zoi190664
                10.1001/jamanetworkopen.2019.17571
                6991205
                31834399
                258b6a18-8164-4432-83ad-63b40393a1ab
                Copyright 2019 Goldman-Mellor S et al. JAMA Network Open.

                This is an open access article distributed under the terms of the CC-BY License.

                History
                : 26 July 2019
                : 27 October 2019
                Funding
                Funded by: National Institutes of Health
                Categories
                Research
                Original Investigation
                Online Only
                Psychiatry

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