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      Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery.

      1 ,
      Journal of pharmaceutical sciences
      American Chemical Society (ACS)

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          Abstract

          The objective of this Review is to summarize and critique recent findings and applications of both unmodified and modified cyclodextrins for in vivo drug delivery. This review focuses on the use of cyclodextrins for parenteral, oral, ophthalmic, and nasal drug delivery. Other routes including dermal, rectal, and pulmonary delivery are also briefly addressed. This Review primarily focuses on newer findings concerning cyclodextrin derivatives which are likely to receive regulatory acceptance due to improved aqueous solubility and safety profiles as compared to the unmodified cyclodextrins. Many of the applications reviewed involve the use of hydroxypropyl-beta-cyclodextrins (HP-beta-CDs) and sulfobutylether-beta-cyclodextrins (SBE-beta-CDs) which show promise of greater safety while maintaining the ability to form inclusion complexes. The advantages and limitations of HP-beta-CD, SBE-beta-CD, and other cyclodextrins are addressed.

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          Author and article information

          Journal
          J Pharm Sci
          Journal of pharmaceutical sciences
          American Chemical Society (ACS)
          0022-3549
          0022-3549
          Nov 1996
          : 85
          : 11
          Affiliations
          [1 ] Higuchi Biosciences Center for Drug Delivery Research, Lawrence, KS, USA.
          Article
          S0022-3549(15)50179-2
          10.1021/js960075u
          8923319
          2560a72d-32a2-4220-ad07-e1f3cafefdeb
          History

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