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Abstract
Oxygen generating biomaterials represent a new trend in regenerative medicine that
aims to generate and supply oxygen at the site of requirement, to support tissue healing
and regeneration. To enhance the healing of dermal wounds, we have developed a highly
portable, in situ oxygen generating wound dressings that uses sodium percarbonate
(SPO) and calcium peroxide (CPO) as chemical oxygen sources. The dressing continuously
generated oxygen for more than 3 days, after which it was replaced. In the in vivo
testing on porcine full-thickness porcine wound model, the SPO/CPO dressing showed
enhanced wound healing during the 8 week study period. Quantitative measurements of
wound healing related parameters, such as wound closure, reepithelialization, epidermal
thickness and collagen content of dermis showed that supplying oxygen topically using
the SPO/CPO dressing significantly accelerated the wound healing. An increase in neovascularization,
as determined using Von Willebrand factor (vWF) and CD31 staining, was also observed
in the presence of SPO/CPO dressing. This novel design for a wound dressing that contains
oxygen generating biomaterials (SPO/CPO) for supplying topical oxygen, may find utility
in treating various types of acute to chronic wounds.