Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy.

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Abstract

We utilized albumin as a reducing agent to establish novel copper-based and pH-sensitive nanocarrier CuNPs with abundant Cu+, which can encapsulate histone deacetylase (HDAC) inhibitor vorinostat to form uniform and stable nanomedicine V-CuNPs for synergistic chromatin remodelling and chemodynamic therapy.

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Journal

Journal ID (iso-abbrev): Chem Commun (Camb)

Title: Chemical communications (Cambridge, England)

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 1364-548X

ISSN (Print): 1359-7345

Publication date (Electronic): Jul 14 2020

Volume: 56

Issue: 56

Affiliations

[1 ] State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China. huyiqiao@nju.edu.cn yuannju@nju.edu.cn.

[2 ] State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University & School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China. huyiqiao@nju.edu.cn yuannju@nju.edu.cn and Institute of Drug R&D, Nanjing University, Nanjing 210093, P. R. China and Jiangsu Provincial Key Laboratory for Nano Technology, Nanjing University, Nanjing, 210093, P. R. China.

Article

DOI: 10.1039/d0cc00165a

PubMed ID: 32613216

SO-VID: 24bdb2c6-c086-4864-ab65-964de0288ab4

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