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      Utility of the Glabellar Flap in the Reconstruction of Medial Canthal Tumors after Mohs Surgery

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          Abstract

          The goals of periorbital region reconstruction are to obtain both functional and esthetic results. Medial canthus is the second most common periorbital location for basal cell carcinoma. If left untreated, it is locally destructive but rarely metastasizes. Incompletely resected medial canthal tumors recur or penetrate along the lacrimal path and expand to wider lesions. A safety margin is necessary to ensure a complete lesion resection. Since it was introduced in 1941, Mohs surgery has been promoted as an efficient method of dealing with infiltrative periorbital skin tumors. It has been shown to have high rates of complete cancer removal during surgery, minimizing the amount of normal tissue loss and securing better functional and cosmetic outcomes. Due to its concave contour and convergence of skin units with variable thickness, texture and mobility, reconstruction of the medial canthal region (MCR) remains challenging. Reconstructive methods such as free full-thickness skin grafts and glabellar flaps have been used alone or in combination with other techniques. The concavity of the canthus must be achieved, but the maintenance of the normal contour and symmetry of the surrounding tissue is critical. The glabellar flap (GF) is a triangular advancement flap that adequately restores the volume in deeper defects, guaranteeing sufficient vascular support without complex or undesirable scars. We present two cases of basal cell carcinoma affecting the MCR that was successfully reconstructed using a GF alone in one case and together with a cheek advancement flap in the second one. In both cases, tumor excision was performed using Mohs surgery.

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          Most cited references30

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          Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota.

          To determine the epidemiologic and clinical characteristics of patients with malignant eyelid tumors in an incidence cohort. Cohort series. A computerized retrieval system was used to identify all patients residing in Olmsted County, Minnesota, who had a newly diagnosed malignant eyelid tumor during the 15-year interval from 1976 through 1990. The patients' medical records were reviewed for demographic and clinical data. Surgical excision with frozen-section histopathologic analysis, Mohs' micrographic excision, and electrodesiccation and curettage were the primary methods of treatment. Survivorship free of tumor. The incidence cohort included 174 patients who each had 1 tumor; men and women were equally affected, and all patients were white. Tumors developed most commonly on the lower eyelid (n = 85; 48.9%) and in the medial canthal region (n = 48; 27.6%) but involved the right and left sides with equal frequency. Of the 174 tumors, 158 were basal cell carcinomas (90.8%), 15 were squamous cell carcinomas (8.6%), and 1 (0.6%) was a malignant melanoma. The age- and gender-adjusted incidence rates for basal cell carcinoma, squamous cell carcinoma, and malignant melanoma were 14.35, 1.37, and 0.08 per 100,000 individuals per year, respectively. No cases of sebaceous gland carcinoma were identified. The 5- and 10-year recurrence rates for all tumors on the eyelid were 2% and 3%, respectively. The probability of an unrelated malignancy developing elsewhere in the body was approximately 9% at 5 years and 15% at 10 years. Basal cell carcinoma is the most common malignant eyelid tumor in whites. The lower eyelid and medial canthus are the most frequent sites of origin. Men and women are equally affected. Recurrence after surgical excision is uncommon.
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            Micrographic surgery for the microscopically controlled excision of eyelid cancers.

            F Mohs (1986)
            Because it allows for the total microscopic control of excision, micrographic surgery is a solution to the problem of determining the exact extent of cancers of the eyelids. The control of excision is achieved by removing successive layers of the affected tissues and microscopically examining the entire undersurface of each layer by the systematic use of frozen sections. The reliability of the method is attested by the five-year cure rates of 99% in 1,773 cases of basal cell carcinoma and of 98.1% in 213 cases of squamous cell carcinoma of the eyelids. Also important is the minimal removal of uninvaded tissue that is feasible because of the precise localization and selective removal of the clinically unpredictable cancerous outgrowths. This saving of normal tissue permits some innovative techniques of wound management.
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              Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment

              Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consist of surgery, vismodegib, radiotherapy and imiquimod. Surgical excision using Mohs micrographic surgery or wide surgical excision with frozen section margin control is the first consideration for treatment of periocular BCC. Eyelid reconstruction should be carefully considered as both function and esthetic outcome in patients are important after clear excision of tumors. Exenteration is considered in the case of extensive orbital invasion or high-risk aggressive tumors in order to reduce the rate of recurrence.
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                Author and article information

                Journal
                Turk J Ophthalmol
                Turk J Ophthalmol
                TJO
                Turkish Journal of Ophthalmology
                Galenos Publishing
                2149-8695
                2149-8709
                April 2021
                29 April 2021
                : 51
                : 2
                : 118-122
                Affiliations
                [1 ]Hospital de Manises, Department of Oculoplastics, Valencia, Spain
                [2 ]Fisabio-oftalmología Médica Department of Oculoplastics, Valencia, Spain
                [3 ]Universitary and Politechnic Hospital la Fe, Department of Radiology, Valencia, Spain
                [4 ]Clinic and Provincial Hospital of Barcelona, Department of Ophthalmology, Barcelona, Spain
                Author notes
                * Address for Correspondence: Hospital de Manises, Department of Oculoplastics, Valencia, Spain E-mail: riediaz@ 123456gmail.com
                Author information
                https://orcid.org/0000-0002-0789-0961
                https://orcid.org/0000-0002-7093-2570
                https://orcid.org/0000-0002-4603-1027
                https://orcid.org/0000-0001-6934-6550
                Article
                47353
                10.4274/tjo.galenos.2020.04641
                8109041
                33951901
                24af6a1c-306b-4719-96b9-4c7cfdc17713
                © Copyright 2021 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 25 May 2020
                : 7 December 2020
                Categories
                Case Report

                basal cell carcinoma,glabellar flap,medial canthus,mohs surgery

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