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Biomacromolecules as carriers in drug delivery and tissue engineering
review-article
09 December 2017
ABD, albumin binding domain,
ACM, aclacinomycin,
ACS, absorbable collagen sponge,
ADH, adipic dihydrazide,
ART, artemisinin,
ASF, Antheraea mylitta silk fibroin,
ATRA, all-trans retinoic acid,
ATS, artesunate,
BCEC, brain capillary endothelial cells,
BMP-2, bone morphogenetic protein-2,
BSA, bovine serum albumin,
BSF, Bombyx mori silk fibroin,
CC-HAM, core-crosslinked polymeric micelle based hyaluronic acid,
CD, cyclodextrin,
CD/BP, cyclodextrin–bisphosphonate complexes,
CD-g-CS, chitosan grafted with β-cyclodextrin,
CD-NPs, amphiphilic MMA–tBA β-CD star copolymers that are capable of forming nanoparticles,
CIA, collagen-induced arthritis,
CM, collagen matrices,
CMD-ChNP, carboxylmethyl dextran chitosan nanoparticle,
DHA, dihydroartesunate,
DOXO-EMCH, (6-maleimidocaproyl)hydrazone derivative of doxorubicin,
DOX–TRF, doxorubincin–transferrin conjugate,
DTX-HPLGA, HA coated PLGA nanoparticulate docetaxel,
ECM, extracellular matrix,
EMT, epithelial mesenchymal transition,
EPR, enhanced permeability and retention,
FcRn, neonatal Fc receptor,
GAG, glycosaminoglycan,
GC-DOX, glycol–chitosan–doxorubicin conjugate,
Gd, gadolinium,
GDNF, glial-derived neurotrophic factor,
GO, grapheme oxide,
GSH, glutathione,
HA, hyaluronic acid,
HA-CA, catechol-modified hyaluronic acid,
HCF, heparin-conjugated fibrin,
HDL, high density lipoprotein,
HEK, human embryonic kidney,
HSA, human serum albumin,
IDL, intermediate density lipoprotein,
INF, interferon,
LDL, low density lipoprotein,
LDLR, low density lipoprotein receptor,
LDV, leucine–aspartic acid–valine,
LMWH, low molecular weight heparin,
MSA, mouse serum albumin,
MTX–HSA, methotrexate–albumin conjugate,
NIR, near-infrared,
NSCLC, non-small cell lung cancer,
OP-Gel-NS, oxidized pectin-gelatin-nanosliver,
pDNA, plasmid DNA,
PEC, polyelectrolyte,
PTX, paclitaxel,
RES, reticuloendothelial system,
RGD, Arg–Gly–Asp peptide,
rHDL, recombinant HDL,
rhEGF-2/HA, recombinant human fibroblast growth factor type 2 in a hyaluronic acid carrier ,
SF, silk fibroin,
SF-CSNP, silk fibroin modified chitosan nanoparticle,
SFNP, silk fibroin nanoparticle,
SPARC, secreted protein acidic and rich in cysteine,
Tf, transferrin,
TfR, transferrin receptor,
TRAIL, tumor-necrosis factor-related apoptosis-inducing ligand,
VEGF, vascular endothelial growth factor,
VLDL, very low density lipoprotein,
Biomacromolecule,
Protein,
Polysaccharide,
Drug delivery,
Tissue engineering
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Abstract
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability, nontoxicity, biocompatibility, biodegradability, long blood circulation time and targeting ability. Recent advances in our understanding of the biological functions of natural-origin biomacromolecules and the progress in the study of biological drug carriers indicate that such carriers may have advantages over synthetic material-based carriers in terms of half-life, stability, safety and ease of manufacture. In this review, we give a brief introduction to the biochemical properties of the widely used biomacromolecule-based carriers such as albumin, lipoproteins and polysaccharides. Then examples from the clinic and in recent laboratory development are summarized. Finally the current challenges and future prospects of present biological carriers are discussed.
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Author and article information
abd, albumin binding domain,acm, aclacinomycin,acs, absorbable collagen sponge,adh, adipic dihydrazide,art, artemisinin,asf, antheraea mylitta silk fibroin,atra, all-trans retinoic acid,ats, artesunate,bcec, brain capillary endothelial cells,bmp-2, bone morphogenetic protein-2,bsa, bovine serum albumin,bsf, bombyx mori silk fibroin,cc-ham, core-crosslinked polymeric micelle based hyaluronic acid,cd, cyclodextrin,cd/bp, cyclodextrin–bisphosphonate complexes,cd-g-cs, chitosan grafted with β-cyclodextrin,cd-nps, amphiphilic mma–tba β-cd star copolymers that are capable of forming nanoparticles,cia, collagen-induced arthritis,cm, collagen matrices,cmd-chnp, carboxylmethyl dextran chitosan nanoparticle,dha, dihydroartesunate,doxo-emch, (6-maleimidocaproyl)hydrazone derivative of doxorubicin,dox–trf, doxorubincin–transferrin conjugate,dtx-hplga, ha coated plga nanoparticulate docetaxel,ecm, extracellular matrix,emt, epithelial mesenchymal transition,epr, enhanced permeability and retention,fcrn, neonatal fc receptor,gag, glycosaminoglycan,gc-dox, glycol–chitosan–doxorubicin conjugate,gd, gadolinium,gdnf, glial-derived neurotrophic factor,go, grapheme oxide,gsh, glutathione,ha, hyaluronic acid,ha-ca, catechol-modified hyaluronic acid,hcf, heparin-conjugated fibrin,hdl, high density lipoprotein,hek, human embryonic kidney,hsa, human serum albumin,idl, intermediate density lipoprotein,inf, interferon,ldl, low density lipoprotein,ldlr, low density lipoprotein receptor,ldv, leucine–aspartic acid–valine,lmwh, low molecular weight heparin,msa, mouse serum albumin,mtx–hsa, methotrexate–albumin conjugate,nir, near-infrared,nsclc, non-small cell lung cancer,op-gel-ns, oxidized pectin-gelatin-nanosliver,pdna, plasmid dna,pec, polyelectrolyte,ptx, paclitaxel,res, reticuloendothelial system,rgd, arg–gly–asp peptide,rhdl, recombinant hdl,rhegf-2/ha, recombinant human fibroblast growth factor type 2 in a hyaluronic acid carrier,sf, silk fibroin,sf-csnp, silk fibroin modified chitosan nanoparticle,sfnp, silk fibroin nanoparticle,sparc, secreted protein acidic and rich in cysteine,tf, transferrin,tfr, transferrin receptor,trail, tumor-necrosis factor-related apoptosis-inducing ligand,vegf, vascular endothelial growth factor,vldl, very low density lipoprotein,biomacromolecule,protein,polysaccharide,drug delivery,tissue engineering
abd, albumin binding domain, acm, aclacinomycin, acs, absorbable collagen sponge, adh, adipic dihydrazide, art, artemisinin, asf, antheraea mylitta silk fibroin, atra, all-trans retinoic acid, ats, artesunate, bcec, brain capillary endothelial cells, bmp-2, bone morphogenetic protein-2, bsa, bovine serum albumin, bsf, bombyx mori silk fibroin, cc-ham, core-crosslinked polymeric micelle based hyaluronic acid, cd, cyclodextrin, cd/bp, cyclodextrin–bisphosphonate complexes, cd-g-cs, chitosan grafted with β-cyclodextrin, cd-nps, amphiphilic mma–tba β-cd star copolymers that are capable of forming nanoparticles, cia, collagen-induced arthritis, cm, collagen matrices, cmd-chnp, carboxylmethyl dextran chitosan nanoparticle, dha, dihydroartesunate, doxo-emch, (6-maleimidocaproyl)hydrazone derivative of doxorubicin, dox–trf, doxorubincin–transferrin conjugate, dtx-hplga, ha coated plga nanoparticulate docetaxel, ecm, extracellular matrix, emt, epithelial mesenchymal transition, epr, enhanced permeability and retention, fcrn, neonatal fc receptor, gag, glycosaminoglycan, gc-dox, glycol–chitosan–doxorubicin conjugate, gd, gadolinium, gdnf, glial-derived neurotrophic factor, go, grapheme oxide, gsh, glutathione, ha, hyaluronic acid, ha-ca, catechol-modified hyaluronic acid, hcf, heparin-conjugated fibrin, hdl, high density lipoprotein, hek, human embryonic kidney, hsa, human serum albumin, idl, intermediate density lipoprotein, inf, interferon, ldl, low density lipoprotein, ldlr, low density lipoprotein receptor, ldv, leucine–aspartic acid–valine, lmwh, low molecular weight heparin, msa, mouse serum albumin, mtx–hsa, methotrexate–albumin conjugate, nir, near-infrared, nsclc, non-small cell lung cancer, op-gel-ns, oxidized pectin-gelatin-nanosliver, pdna, plasmid dna, pec, polyelectrolyte, ptx, paclitaxel, res, reticuloendothelial system, rgd, arg–gly–asp peptide, rhdl, recombinant hdl, rhegf-2/ha, recombinant human fibroblast growth factor type 2 in a hyaluronic acid carrier, sf, silk fibroin, sf-csnp, silk fibroin modified chitosan nanoparticle, sfnp, silk fibroin nanoparticle, sparc, secreted protein acidic and rich in cysteine, tf, transferrin, tfr, transferrin receptor, trail, tumor-necrosis factor-related apoptosis-inducing ligand, vegf, vascular endothelial growth factor, vldl, very low density lipoprotein, biomacromolecule, protein, polysaccharide, drug delivery, tissue engineering