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      Programmed Release of Dihydroartemisinin for Synergistic Cancer Therapy Using a CaCO 3 Mineralized Metal–Organic Framework

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          Abstract

          <p class="first" id="d698384e101">Dihydroartemisinin (DHA) has attracted increasing attention as an anticancer agent. However, using DHA to treat cancer usually depends on the synergistic effects of exogenous components, and the loss of DHA during delivery reduces its effectiveness in cancer therapy. Reported herein is a programmed release nanoplatform of DHA to synergistically treat cancer with a Fe-TCPP [(4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis(benzoic acid)] NMOF (nanoscale MOF) having a CaCO3 mineralized coating, which prevents DHA leakage during transport in the bloodstream. When the nanoplatform arrives at the tumor site, the weakly acidic microenvironment and high concentration of glutathione (GSH) trigger DHA release and TCPP activation, enabling the synergistic Fe2+ -DHA-mediated chemodynamic therapy, Ca2+ -DHA-mediated oncosis therapy, and TCPP-mediated photodynamic therapy. In vivo experiments demonstrated that the nanoplatform showed enhanced anticancer efficiency and negligible toxicity. </p>

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          Author and article information

          Contributors
          Journal
          Angewandte Chemie International Edition
          Angew. Chem. Int. Ed.
          Wiley
          1433-7851
          1521-3773
          October 2019
          August 28 2019
          October 2019
          : 58
          : 40
          : 14134-14139
          Affiliations
          [1 ]College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes Ministry of Education Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China
          Article
          10.1002/anie.201907388
          31389105
          23f2b1d5-38b1-4af3-8495-25d5b8c553e9
          © 2019

          http://onlinelibrary.wiley.com/termsAndConditions#vor

          http://doi.wiley.com/10.1002/tdm_license_1.1

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