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      Introduction to biosensors

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          Abstract

          Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. A wide range of techniques can be used for the development of biosensors. Their coupling with high-affinity biomolecules allows the sensitive and selective detection of a range of analytes. We give a general introduction to biosensors and biosensing technologies, including a brief historical overview, introducing key developments in the field and illustrating the breadth of biomolecular sensing strategies and the expansion of nanotechnological approaches that are now available.

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          Surface plasmon resonance for gas detection and biosensing

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            Glucose Biosensors: An Overview of Use in Clinical Practice

            Blood glucose monitoring has been established as a valuable tool in the management of diabetes. Since maintaining normal blood glucose levels is recommended, a series of suitable glucose biosensors have been developed. During the last 50 years, glucose biosensor technology including point-of-care devices, continuous glucose monitoring systems and noninvasive glucose monitoring systems has been significantly improved. However, there continues to be several challenges related to the achievement of accurate and reliable glucose monitoring. Further technical improvements in glucose biosensors, standardization of the analytical goals for their performance, and continuously assessing and training lay users are required. This article reviews the brief history, basic principles, analytical performance, and the present status of glucose biosensors in the clinical practice.
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              Emerging pollutants in the environment: present and future challenges in biomonitoring, ecological risks and bioremediation.

              Emerging pollutants reach the environment from various anthropogenic sources and are distributed throughout environmental matrices. Although great advances have been made in the detection and analysis of trace pollutants during recent decades, due to the continued development and refinement of specific techniques, a wide array of undetected contaminants of emerging environmental concern need to be identified and quantified in various environmental components and biological tissues. These pollutants may be mobile and persistent in air, water, soil, sediments and ecological receptors even at low concentrations. Robust data on their fate and behaviour in the environment, as well as on threats to ecological and human health, are still lacking. Moreover, the ecotoxicological significance of some emerging micropollutants remains largely unknown, because satisfactory data to determine their risk often do not exist. This paper discusses the fate, behaviour, (bio)monitoring, environmental and health risks associated with emerging chemical (pharmaceuticals, endocrine disruptors, hormones, toxins, among others) and biological (bacteria, viruses) micropollutants in soils, sediments, groundwater, industrial and municipal wastewaters, aquaculture effluents, and freshwater and marine ecosystems, and highlights new horizons for their (bio)removal. Our study aims to demonstrate the imperative need to boost research and innovation for new and cost-effective treatment technologies, in line with the uptake, mode of action and consequences of each emerging contaminant. We also address the topic of innovative tools for the evaluation of the effects of toxicity on human health and for the prediction of microbial availability and degradation in the environment. Additionally, we consider the development of (bio)sensors to perform environmental monitoring in real-time mode. This needs to address multiple species, along with a more effective exploitation of specialised microbes or enzymes capable of degrading endocrine disruptors and other micropollutants. In practical terms, the outcomes of these activities will build up the knowledge base and develop solutions to fill the significant innovation gap faced worldwide.
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                Author and article information

                Journal
                Essays Biochem
                Essays Biochem
                ppebio
                BSE
                BSE
                Essays in Biochemistry
                Portland Press Limited
                0071-1365
                1744-1358
                30 June 2016
                30 June 2016
                : 60
                : 1 , Biosensor Technologies for Detection of Biomolecules ( displayID: 1 )
                : 1-8
                Affiliations
                Department of Electronic and Electrical Engineering, University of Bath, Bath BA2 7AY, U.K.
                Author notes
                Correspondence: Pedro Estrela ( p.estrela@ 123456bath.ac.uk )
                Article
                EBC20150001
                10.1042/EBC20150001
                4986445
                27365030
                23b19509-5c05-4883-bf90-c131161fea16
                © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
                History
                Page count
                Figures: 2, Tables: 1, References: 28, Pages: 8
                Categories
                Article

                affinity reagents,biosensors,glucose sensor,nanomaterials,pregnancy test

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