Consolidation phenomena in laser and powder-bed based layered manufacturing

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Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering.

Jessica Williams, Adebisi Adewunmi, Rachel Schek … (2005)

Polycaprolactone (PCL) is a bioresorbable polymer with potential applications for bone and cartilage repair. In this work, porous PCL scaffolds were computationally designed and then fabricated via selective laser sintering (SLS), a rapid prototyping technique. The microstructure and mechanical properties of the fabricated scaffolds were assessed and compared to the designed porous architectures and computationally predicted properties. Scaffolds were then seeded with bone morphogenetic protein-7 (BMP-7) transduced fibroblasts and implanted subcutaneously to evaluate biological properties and to demonstrate tissue in-growth. The work done illustrates the ability to design and fabricate PCL scaffolds with porous architecture that have sufficient mechanical properties for bone tissue engineering applications using SLS. Compressive modulus and yield strength values ranged from 52 to 67 MPa and 2.0 to 3.2 Mpa, respectively, lying within the lower range of properties reported for human trabecular bone. Finite element analysis (FEA) results showed that mechanical properties of scaffold designs and of fabricated scaffolds can be computationally predicted. Histological evaluation and micro-computed tomography (microCT) analysis of implanted scaffolds showed that bone can be generated in vivo. Finally, to demonstrate the clinical application of this technology, we designed and fabricated a prototype mandibular condyle scaffold based on an actual pig condyle. The integration of scaffold computational design and free-form fabrication techniques presented here could prove highly useful for the construction of scaffolds that have anatomy specific exterior architecture derived from patient CT or MRI data and an interior porous architecture derived from computational design optimization.

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Selective laser melting of iron-based powder

J.P. Kruth, L Froyen, J. Van Vaerenbergh … (2004)

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Binding mechanisms in selective laser sintering and selective laser melting

J-P Kruth, L Froyen, J. Van Vaerenbergh … (2005)

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Author and article information

Journal

Title: CIRP Annals - Manufacturing Technology

Abbreviated Title: CIRP Annals - Manufacturing Technology

Publisher: Elsevier BV

ISSN (Print): 00078506

Publication date Created: 2007

Publication date (Print): 2007

Volume: 56

Issue: 2

Pages: 730-759

Article

DOI: 10.1016/j.cirp.2007.10.004

SO-VID: 235da154-12db-4e57-924a-f73bdac356f6

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http://www.elsevier.com/tdm/userlicense/1.0/

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