Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation.

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Abstract

Er-Miao-San (EMS) is a traditional Chinese herbal formulation that contains combinations of Rhizoma Atractylodis (RA) and Cortex Phellodendri (CP). It exhibits analgesic and anti-inflammatory activities and have been used for the treatment of various "Bi Zheng" for thousand years in China. The aims of the present study were to investigate the anti-inflammatory activities of EMS and elucidate the underlying mechanisms with regard to its molecular basis of action for the best combination.

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Journal ID (iso-abbrev): J Ethnopharmacol

Title: Journal of ethnopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1872-7573

ISSN (Print): 0378-8741

Publication date (Electronic): Jul 03 2014

Volume: 154

Issue: 3

Affiliations

[1 ] School of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing 400067, China.

[2 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.

[3 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People׳s Republic of China.. Electronic address: pingcleung@cuhk.edu.hk.

[4 ] State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China; CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People׳s Republic of China.. Electronic address: gohey@cuhk.edu.hk.

Article

Publisher Item ID: S0378-8741(14)00330-4

DOI: 10.1016/j.jep.2014.04.042

PubMed ID: 24815219

SO-VID: 22440461-d174-495e-a1f6-d28bb43845ae

History

Keywords: Er-Miao-San,Inducible nitric oxide synthase,Nitric oxide,Nuclear factor-κB,P38,Traditional Chinese medicine

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Keywords: Er-Miao-San, Inducible nitric oxide synthase, Nitric oxide, Nuclear factor-κB, P38, Traditional Chinese medicine

Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation.

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