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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
G Steinbach
1 ,
P M Lynch ,
R K Phillips ,
M H Wallace ,
E Hawk ,
G B Gordon ,
N Wakabayashi ,
B Saunders ,
Y Shen ,
T Fujimura ,
L K Su ,
B Levin ,
L Godio ,
S Patterson ,
M A Rodriguez-Bigas ,
S L Jester ,
K L King ,
M Schumacher ,
J Abbruzzese ,
R N DuBois ,
W N Hittelman ,
S Zimmerman ,
J W Sherman ,
G Kelloff
Jun 29 2000
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Abstract
Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroidal antiinflammatory drugs may be related to their inhibition of cyclooxygenase-2.
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