Analyzing the multi-target pharmacological mechanism of folium <i>Artemisia argyi</i> acting on breast cancer: a network pharmacology approach

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Abstract

Background

Folium Artemisia argyi (FAA) is a traditional Chinese herbal medicine that is widely used in the clinic. However, the underlying mechanisms of its anticancer effects have not been fully elucidated.

Methods

In this study, we applied a network pharmacology approach to identify the potential mechanisms of FAA against breast cancer. To be specific, we screened the active ingredients and potential targets of the FAA through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Meanwhile, we employed the oral bioavailability (OB) and drug-likeness (DL) to search for potential bioactive compounds of FAA. Breast cancer-related target genes data were gathered from the GeneCards and Online Mendelian Inheritance in Man (OMIM) databases, and the protein-protein interaction (PPI) data were acquired from the Search Tool for the Retrieval of Interacting Genes (STRING) database. In addition, we constructed the network and performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway Enrichment Analysis.

Results

We obtained a total of nine active ingredients and 236 potential targets from FAA to construct a network, which showed that quercetin served as the major ingredient in FAA. AKT1 (RAC-alpha serine/threonine-protein kinase), MYC (Myc proto-oncogene protein), CASP3 (Caspase-3), EGFR (Epidermal growth factor receptor), JUN (Transcription factor AP-1), CCND1 (G1/S-specific cyclin-D1), VEGFA (Vascular endothelial growth factor A), ESR1 (Estrogen receptor), MAPK1 (Mitogen-activated protein kinase 1), and EGF (pro-epidermal growth factor) were identified as key targets of FAA in the treatment of breast cancer. The PPI cluster demonstrated that AKT1 was the seed in this cluster, indicating that AKT1 played a crucial role in connecting other nodes in the PPI network. This enrichment demonstrated that FAA was highly related to signal transduction, endocrine system, replication and repair, as well as cell growth and death. The enrichment results also verified that the underlying mechanisms of FAA against breast cancer might be attributed to the coordinated regulation of several cancer-related pathways, such as the MAPK and mammalian target of rapamycin (mTOR) signaling pathways, among others.

Conclusions

This study identified the potential targets and pathways of FAA in the treatment of breast cancer using a network pharmacology approach, and systematically elucidated the mechanisms of FAA in the treatment of breast cancer.

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Most cited references 65

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Author and article information

Journal

Journal ID (nlm-ta): Ann Transl Med

Journal ID (iso-abbrev): Ann Transl Med

Journal ID (publisher-id): ATM

Title: Annals of Translational Medicine

Publisher: AME Publishing Company

ISSN (Print): 2305-5839

ISSN (Electronic): 2305-5847

Publication date (Print and electronic): December 2022

Publication date (Print): December 2022

Volume: 10

Issue: 24

Electronic Location Identifier: 1368

Affiliations

[1 ]deptDepartment of Medical Oncology, Harbin Medical University Cancer Hospital , Harbin Medical University , Harbin, China;

[2 ]deptDepartment of Clinical Laboratory , The Seventh Hospital in Qiqihar , Qiqihar, China;

[3 ]deptInstitute of Cancer Prevention and Treatment , Harbin Medical University , Harbin, China;

[4 ]Heilongjiang Academy of Medical Sciences , Harbin, China

Author notes

Contributions: (I) Conception and design: Q Zhang; (II) Administrative support: Q Zhang, H Ji; (III) Provision of study materials or patients: X Wang, H Zhang, X Niu, Y Yang, X Yang; (IV) Collection and assembly of data: L Yin, Y Wang, C Zhang, R Shui; (V) Data analysis and interpretation: Ying Song, J Wang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

[#]

These authors contributed equally to this work.

Correspondence to: Qingyuan Zhang. Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China. Email: zqyHMU1965@ 123456163.com ; Hongfei Ji. Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin 150081, China. Email: jihongfei@ 123456hrbmu.edu.cn .

Article

Publisher ID: atm-10-24-1368

DOI: 10.21037/atm-22-5769

PMC ID: 9843367

SO-VID: 222fd7cc-d002-4bf6-be02-dc9173a72572

License:

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

Analyzing the multi-target pharmacological mechanism of folium Artemisia argyi acting on breast cancer: a network pharmacology approach

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Abstract

Background

Methods

Results

Conclusions

Related collections

Karger: Oncology

Most cited references 65

Gene Ontology: tool for the unification of biology

Cytoscape: a software environment for integrated models of biomolecular interaction networks.

KEGG: kyoto encyclopedia of genes and genomes.

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