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Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa
Mrinal K Sarkar ,
Grace A Hile ,
Lam C Tsoi ,
Xianying Xing ,
Jianhua Liu ,
Yun Liang ,
Celine C Berthier ,
William R Swindell ,
Matthew T Patrick ,
Shuai Shao ,
Pei-Suen Tsou ,
Ranjitha Uppala ,
Maria A Beamer ,
Anshika Srivastava ,
Stephanie L Bielas ,
Paul W Harms ,
Spiro Getsios ,
James T Elder ,
John J Voorhees ,
Johann E Gudjonsson ,
J Michelle Kahlenberg
July 18 2018
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Abstract
Skin inflammation and photosensitivity are common in patients with cutaneous lupus
erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about
the mechanisms that regulate these traits. Here we investigate the role of interferon
kappa (IFN-κ) in regulation of type I interferon (IFN) and photosensitive responses
and examine its dysregulation in lupus skin.