Aleksi J. Nummela:
ORCID: https://orcid.org/0000-0001-6679-4753
Role: Data curationRole: Funding acquisitionRole: SoftwareRole: ValidationRole: VisualizationRole:
Writing – original draft
Harry Scheinin: Role: ConceptualizationRole: Writing – review & editing
Markus Perola: Role: Writing – review & editing
Anni Joensuu:
ORCID: https://orcid.org/0000-0002-7547-7458
Role: Formal analysisRole: Writing – review & editing
Ruut Laitio: Role: InvestigationRole: Writing – review & editing
Olli Arola: Role: InvestigationRole: Writing – review & editing
Juha Grönlund: Role: InvestigationRole: Writing – review & editing
Risto O. Roine: Role: Funding acquisitionRole: Writing – review & editing
Minna Bäcklund: Role: InvestigationRole: Writing – review & editing
Tero J. Vahlberg: Role: Formal analysisRole: ValidationRole: Writing – review & editing
Timo Laitio: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: Writing
– review & editing
Jae Hee Kang: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
4
June
2024
Publication date Collection: 2024
Volume: 19
Issue: 6
Electronic Location Identifier: e0304966
Affiliations
[1
]
Department of Internal Medicine, Turku University Hospital, University of Turku, Turku,
Finland
[2
]
Department of Perioperative Services, Intensive Care and Pain Management, Turku University
Hospital, University of Turku, Turku, Finland
[3
]
Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku,
Turku, Finland
[4
]
Finnish Institute for Health and Welfare, Helsinki, Finland
[5
]
Faculty of Medicine, Research Program for Clinical and Molecular Metabolism, University
of Helsinki, Helsinki, Finland
[6
]
Division of Clinical Neurosciences, University of Turku, Turku University Hospital,
Turku, Finland
[7
]
Department of Anesthesiology, Intensive Care and Pain Medicine, Division of Intensive
Care Medicine, University of Helsinki and HUS Helsinki University Hospital, Helsinki,
Finland
[8
]
Department of Biostatistics, University of Turku and Turku University Hospital, Turku,
Finland
Brigham and Women’s Hospital, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
¶ The membership of Xe-Hypotheca Collaboration Group is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PONE-D-23-27984
DOI: 10.1371/journal.pone.0304966
PMC ID: 11149864
PubMed ID: 38833442
SO-VID: 219d091e-fa66-4c67-9cab-1829f5e57f6d
Copyright © © 2024 Nummela et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/501100002341, Academy of Finland;
Award ID: 128235
Award Recipient
:
Risto O. Roine
Funded by:
funder-id http://dx.doi.org/10.13039/501100005609, Turun Yliopisto;
Award Recipient
:
ORCID: https://orcid.org/0000-0001-6679-4753
Aleksi J. Nummela
Funded by:
State Research Funding
Award Recipient
:
Timo Laitio
Academy of Finland, Helsinki, Finland (R.R), grant number 128235,
https://www.aka.fi/en/ State Research Funding (T.L), no grant number,
https://www.varha.fi/fi/tietoa-varhasta/tieteellinen-tutkimus/tutkimusrahoitus/valtion-tutkimusrahoitus/valtion-tutkimusrahoitushaku-vuodelle-2024 University of Turku and Turku PET center (A.N.), worked as a paid full-time researcher,
no grant number.
https://turkupetcentre.fi/ The funders had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Elements
Subject:
Xenon
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolites
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Valine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Valine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Valine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Alanine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Leucine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Leucine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Aliphatic Amino Acids
Subject:
Leucine
Subject:
Research and analysis methods
Subject:
Spectrum analysis techniques
Subject:
NMR spectroscopy
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Glutamate
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Glutamate
Subject:
Biology and Life Sciences
Subject:
Population Biology
Subject:
Population Metrics
Subject:
Death Rates
