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      Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment.

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          Abstract

          The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (ml), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo 1H magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain ml level. The ratio of ml over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change -18%) in Ts65Dn mice (n=5) compared with control mice (n= 7). This is consistent with 1H MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n= 12) was reduced (mean change -15%) following Li treatment, supporting the Li-induced ml depletion hypothesis.

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          Author and article information

          Journal
          Neuroreport
          Neuroreport
          Ovid Technologies (Wolters Kluwer Health)
          0959-4965
          0959-4965
          Feb 28 2000
          : 11
          : 3
          Affiliations
          [1 ] Laboratory of Neurosciences/NIA, Bethesda, MD 20892, USA.
          Article
          10.1097/00001756-200002280-00004
          10718292
          219174ac-c0cd-4fec-a055-c2d0b258cbdb
          History

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