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Effects of HIV infection and antiretroviral therapy with ritonavir on induction of osteoclast-like cells in postmenopausal women.
M T Yin
1 ,
R Modarresi ,
E Shane ,
F Santiago ,
D C Ferris ,
D J McMahon ,
C A Zhang ,
S Cremers ,
J Laurence
May 2011
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Abstract
Ritonavir (RTV) is a commonly used antiretroviral associated with bone loss. We show that peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus (HIV)-positive women on RTV are more likely to differentiate into osteoclast-like cells when cultured with their own sera than PBMCs and sera from HIV- women or HIV+ on other antiretrovirals.