Mycobacterium abscessus Complex Infections in Humans

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Abstract

New treatments, rapid and inexpensive identification methods, and measures to contain nosocomial transmission and outbreaks are urgently needed.

Abstract

Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections. M. abscessus complex is differentiated into 3 subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. massiliense, and M. abscessus subsp. bolletii. The 2 major subspecies, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, have different erm(41) gene patterns. This gene provides intrinsic resistance to macrolides, so the different patterns lead to different treatment outcomes. M. abscessus complex outbreaks associated with cosmetic procedures and nosocomial transmissions are not uncommon. Clarithromycin, amikacin, and cefoxitin are the current antimicrobial drugs of choice for treatment. However, new treatment regimens are urgently needed, as are rapid and inexpensive identification methods and measures to contain nosocomial transmission and outbreaks.

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Adult-Onset Immunodeficiency in Thailand and Taiwan

Sarah Browne, Peter D. Burbelo, Ploenchan Chetchotisakd … (2012)

New England Journal of Medicine, 367(8), 725-734

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A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.

Kevin A Nash, Barbara A Brown-Elliott, Richard J Wallace (2009)

Mycobacterium abscessus infections tend to respond poorly to macrolide-based chemotherapy, even though the organisms appear to be susceptible to clarithromycin. Circumstantial evidence suggested that at least some M. abscessus isolates might be inducibly resistant to macrolides. Thus, the purpose of this study was to investigate the macrolide phenotype of M. abscessus clinical isolates. Inducible resistance to clarithromycin (MIC > 32 microg/ml) was found for 7 of 10 clinical isolates of M. abscessus previously considered susceptible; the remaining 3 isolates were deemed to be susceptible (MIC

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Increasing Incidence of Nontuberculous Mycobacteria, Taiwan, 2000–2008

Chih-Cheng Lai, Che-Kim Tan, Chien-Hong Chou … (2010)

To assess the species distribution and epidemiologic trends of nontuberculous mycobacteria, we examined isolates from patients in Taiwan. During 2000–2008, the proportion increased significantly from 32.3% to 49.8%. Associated disease incidence increased from 2.7 to 10.2 cases per 100,000 patients. Mycobacterium avium complex and M. abscessus were most frequently isolated.

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Journal

Journal ID (nlm-ta): Emerg Infect Dis

Journal ID (iso-abbrev): Emerging Infect. Dis

Journal ID (publisher-id): EID

Title: Emerging Infectious Diseases

Publisher: Centers for Disease Control and Prevention

ISSN (Print): 1080-6040

ISSN (Electronic): 1080-6059

Publication date (Print): September 2015

Volume: 21

Issue: 9

Pages: 1638-1646

Affiliations

[1]National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan (M.-R. Lee, W.-H. Sheng, C.-C. Hung, C.-J. Yu, L.-N. Lee, P.-R. Hsueh);

[2]National Taiwan University Hospital, Taipei, Taiwan (M.-R. Lee, W.-H. Sheng, C.-C. Hung, C.-J. Yu, L.-N. Lee, P.-R. Hsueh)

Author notes

Address for correspondence: Po-Ren Hsueh, Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; email: hsporen@ 123456ntu.edu.tw

Article

Publisher ID: 14-1634

DOI: 10.3201/2109.141634

PMC ID: 4550155

PubMed ID: 26295364

SO-VID: 204dca4b-7fe9-43ff-85fa-b0b22501ffc3

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Mycobacterium abscessus Complex Infections in Humans

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Mary Ann Liebert: COVID-19 science

Most cited references 29

Adult-Onset Immunodeficiency in Thailand and Taiwan

A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.

Increasing Incidence of Nontuberculous Mycobacteria, Taiwan, 2000–2008

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