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      Role of STAT3 in cancer cell epithelial-mesenchymal transition (Review)

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          Abstract

          Since its discovery, the role of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in both normal physiology and the pathology of numerous diseases, including cancer, has been extensively studied. STAT3 is aberrantly activated in different types of cancer, fulfilling a critical role in cancer progression. The biological process, epithelial-mesenchymal transition (EMT), is indispensable for embryonic morphogenesis. During the development of cancer, EMT is hijacked to confer motility, tumor cell stemness, drug resistance and adaptation to changes in the microenvironment. The aim of the present review was to outline recent advances in knowledge of the role of STAT3 in EMT, which may contribute to the understanding of the function of STAT3 in EMT in various types of cancer. Delineating the underlying mechanisms associated with the STAT3-EMT signaling axis may generate novel diagnostic and therapeutic options for cancer treatment.

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          Epithelial-mesenchymal transitions in development and disease.

          Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang … (2009)
          The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
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            EMT: 2016.

            M. Angela Nieto, Ruby Yun-Ju Huang, Rebecca A. Jackson … (2016)
            The significant parallels between cell plasticity during embryonic development and carcinoma progression have helped us understand the importance of the epithelial-mesenchymal transition (EMT) in human disease. Our expanding knowledge of EMT has led to a clarification of the EMT program as a set of multiple and dynamic transitional states between the epithelial and mesenchymal phenotypes, as opposed to a process involving a single binary decision. EMT and its intermediate states have recently been identified as crucial drivers of organ fibrosis and tumor progression, although there is some need for caution when interpreting its contribution to metastatic colonization. Here, we discuss the current state-of-the-art and latest findings regarding the concept of cellular plasticity and heterogeneity in EMT. We raise some of the questions pending and identify the challenges faced in this fast-moving field.
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              Long non-coding RNAs: insights into functions.

              Tim Mercer, Marcel E Dinger, John S. Mattick (2009)
              In mammals and other eukaryotes most of the genome is transcribed in a developmentally regulated manner to produce large numbers of long non-coding RNAs (ncRNAs). Here we review the rapidly advancing field of long ncRNAs, describing their conservation, their organization in the genome and their roles in gene regulation. We also consider the medical implications, and the emerging recognition that any transcript, regardless of coding potential, can have an intrinsic function as an RNA.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Oncol
                Journal ID (iso-abbrev): Int J Oncol
                Journal ID (publisher-id): IJO
                Title: International Journal of Oncology
                Publisher: D.A. Spandidos
                ISSN (Print): 1019-6439
                ISSN (Electronic): 1791-2423
                Publication date Collection: May 2024
                Publication date (Electronic): 13 March 2024
                Publication date PMC-release: 13 March 2024
                Volume: 64
                Issue: 5
                Electronic Location Identifier: 48
                Affiliations
                [1 ]Department of Forensic Genetics, Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Forensic Science Center of Jining Medical University, Jining, Shandong 272067, P.R. China
                [2 ]Department of Forensic Pathology, Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Forensic Science Center of Jining Medical University, Jining, Shandong 272067, P.R. China
                Author notes
                Correspondence to: Dr Wen Cui, Department of Forensic Pathology, Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Forensic Science Center of Jining Medical University, 133 Hehua Road, Jining, Shandong 272067, P.R. China, E-mail: cuiwenmdd@ 123456163.com
                Article
                Publisher ID: ijo-64-05-05636
                DOI: 10.3892/ijo.2024.5636
                PMC ID: 11000535
                PubMed ID: 38488027
                SO-VID: 2041fb64-76e2-4778-97dc-3b3b61ccb0b1
                Copyright © Copyright: © 2024 Zhang et al.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

                History
                Date received : 01 August 2023
                Date accepted : 29 February 2024
                Funding
                Funded by: Shandong Provincial Natural Science Foundation
                Award ID: ZR2020MH212
                The present study was supported by the Shandong Provincial Natural Science Foundation (grant no. ZR2020MH212).
                Categories
                Subject: Review

                Keywords: stat3,epithelial-mesenchymal transition,microrna,long non-coding rna
                Data availability:
                Keywords: stat3, epithelial-mesenchymal transition, microrna, long non-coding rna

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