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      Potenciais evocados auditivos tardios em indivíduos com queixa de zumbido Translated title: Late Auditory evoked potentials in individuals with tinnitus

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          Abstract

          A presença de alterações nos potenciais evocados auditivos de longa latência (PEALL) em indivíduos com zumbido sugere disfunção de vias auditivas centrais em nível cortical. OBJETIVO: Caracterizar o PEALL em indivíduos com e sem zumbido expostos a ruído ocupacional. MATERIAL E MÉTODO: Estudo prospectivo, de coorte contemporânea com corte transversal. Foram avaliados, por meio do PEALL, 60 sujeitos expostos a ruído de origem ocupacional, entre 29 e 50 anos de idade, sendo 30 com zumbido e 30 sem zumbido. RESULTADOS: Observou-se diferença estatisticamente significante com relação aos valores médios das latências das ondas N1(p<0,001), P2(p=0,002) e P300(p=0,039) quando comparados entre o grupo de indivíduos com e sem zumbido. Observou-se maior ocorrência de alterações no grupo com zumbido para os componentes N1(60%) e P2(66,7%), porém, apenas para o componente P2 (p=0,010) apresentou diferença estatisticamente significante. Para o PEALL, o aumento de latência foi o único tipo de alteração encontrada (p=1,000). Verificou-se maior associação entre zumbido bilateral e alteração bilateral para todos os componentes N1(73%), P2(73%) e P300(50%). CONCLUSÃO: Há relevância do estudo do PEALL em indivíduos com queixa de zumbido expostos a níveis de pressão sonora de origem ocupacional.

          Translated abstract

          Long latency auditory evoked potentials (LLAEP) alterations in individuals with tinnitus are suggestive of dysfunction in the central auditory pathways at a cortical level. AIM: to characterize the LLAEP in individuals with and without tinnitus exposed to occupational noise. METHOD: Cross-sectional contemporary cohort, prospective study. Sixty subjects exposed to occupational noise, ranging in age from 29 to 50 years underwent LLAEP assessment; 30 of them had tinnitus complaint and 30 did not have tinnitus. RESULTS: we observed significant statistical difference regarding the mean values of latencies of waves N1 (p<0.001), P2 (p=0.002) and P300 (p=0.039) when we compared individuals with and without tinnitus. In individuals with tinnitus we also noticed a greater number of altered results concerning components N1 (60%) and P2 (66.7%), although only component P2 presented significant statistical difference (p=0.010). For the LLAEP, the latency increase was the only type of alteration found (p=1.000). We found a greater association between bilateral tinnitus and bilateral alteration for all components N1(73%), P2(73%) and P300(50%). CONCLUSION: It is relevant to study LLAEP in individuals with tinnitus exposed to high occupational sound pressure levels.

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          Most cited references27

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          The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.

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            The P300 Wave of the Human Event-Related Potential

            The P300 wave is a positive deflection in the human event-related potential. It is most commonly elicited in an "oddball" paradigm when a subject detects an occasional "target" stimulus in a regular train of standard stimuli. The P300 wave only occurs if the subject is actively engaged in the task of detecting the targets. Its amplitude varies with the improbability of the targets. Its latency varies with the difficulty of discriminating the target stimulus from the standard stimuli. A typical peak latency when a young adult subject makes a simple discrimination is 300 ms. In patients with decreased cognitive ability, the P300 is smaller and later than in age-matched normal subjects. The intracerebral origin of the P300 wave is not known and its role in cognition not clearly understood. The P300 may have multiple intracerebral generators, with the hippocampus and various association areas of the neocortex all contributing to the scalp-recorded potential. The P300 wave may represent the transfer of information to consciousness, a process that involves many different regions of the brain.
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              Characterization of tinnitus by tinnitus patients.

              A questionnaire was administered to 528 tinnitus patients to obtain data on their reactions to tinnitus. Results include a discussion of: (a) population characteristics, (b) perceptual characteristics, (c) the impact of tinnitus on daily life, and (d) etiology. Significant gender differences are also discussed. Tinnitus was not an occasional phenomenon, but was present for more than 26 days per month in 74% of the patients. Other important findings about tinnitus include: (a) Hearing levels at 1000 and 4000 Hz were less than or equal to 25 dB HL for 18% of the tinnitus patients, which suggests that some patients had normal hearing or mild hearing losses; (b) the prevalence of tinnitus in patients with noise-induced hearing loss (NIHL) was 30% for males and only 3% for females; (c) about 25% of the patients reported tinnitus severity had increased since tinnitus onset; (d) the effects of tinnitus were more severe in patients who reported tinnitus as their primary complaint and in patients diagnosed as having Ménière's syndrome tinnitus; and (e) some patients reported that noise exacerbated their tinnitus, whereas others reported that a quiet background exacerbated their tinnitus.
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                Author and article information

                Journal
                bjorl
                Brazilian Journal of Otorhinolaryngology
                Braz. j. otorhinolaryngol.
                Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. (São Paulo, SP, Brazil )
                1808-8694
                1808-8686
                April 2010
                : 76
                : 2
                : 263-270
                Affiliations
                [01] orgnameUniversidade de São Paulo orgdiv1Faculdade de Medicina orgdiv2Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional
                Article
                S1808-86942010000200019 S1808-8694(10)07600219
                10.1590/S1808-86942010000200019
                2031e917-df62-4932-a2cc-8b65760960d6

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 11 November 2009
                : 30 June 2009
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 32, Pages: 8
                Product

                SciELO Brazil

                Categories
                Artigos Originais

                ruído ocupacional,eletrofisiologia,tinnitus,noise,occupational,evoked potentials,zumbido,potenciais evocados auditivos

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