Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

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Abstract

Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

Most cited references 158

Record: found
Abstract: not found
Article: not found

Hydrogels for biomedical applications

Allan S Hoffman (2012)

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Record: found
Abstract: not found
Article: not found

Electrospinning of nanofibers

R. Tock, S. Parameswaran, Thandavamoorthy Subbiah … (2005)

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Record: found
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Hyaluronic acid hydrogels for biomedical applications.

Jason A. Burdick, Glenn D. Prestwich (2011)

Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many physical forms-viscoelastic solutions, soft or stiff hydrogels, electrospun fibers, non-woven meshes, macroporous and fibrillar sponges, flexible sheets, and nanoparticulate fluids-for use in a range of preclinical and clinical settings. Many of these forms are derived from the chemical crosslinking of pendant reactive groups by addition/condensation chemistry or by radical polymerization. Clinical products for cell therapy and regenerative medicine require crosslinking chemistry that is compatible with the encapsulation of cells and injection into tissues. Moreover, an injectable clinical biomaterial must meet marketing, regulatory, and financial constraints to provide affordable products that can be approved, deployed to the clinic, and used by physicians. Many HA-derived hydrogels meet these criteria, and can deliver cells and therapeutic agents for tissue repair and regeneration. This progress report covers both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Author and article information

Journal

Title: Nanotechnology Reviews

Publisher: Walter de Gruyter GmbH

ISSN (Electronic): 2191-9097

Publication date Created: November 05 2020

Publication date Created: January 01 2020

Publication date (Print): November 05 2020

Publication date (Electronic): November 05 2020

Publication date (Print): January 01 2020

Volume: 9

Issue: 1

Pages: 1059-1079

Affiliations

[1 ]Department of Orthopaedics, West China Hospital, Sichuan University , 610041 , Chengdu , China

[2 ]National Engineering Research Center for Biomaterials, Sichuan University , 610064 , Chengdu , China

[3 ]College of Biomedical Engineering, Sichuan University , 610064 , Chengdu , China

[4 ]Innovatus Oral Cosmetic & Surgical Institute , Norman , OK, 73069 , United States of America

[5 ]Department of Orthopedics Medical Center, West China School of Public Health and West China Fourth Hospital, Sichuan University , Chengdu , Sichuan , China

[6 ]Department of Biomedical and Chemical Engineering and Sciences, College of Engineering & Science, Florida Institute of Technology , Melbourne , FL, 32901 , United States of America