Hyperuricemia and long-term mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention

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Abstract

Background

Although serum uric acid (UA) was regarded to be involved in cardiovascular disease, the role of serum UA (SUA) as a risk factor in acute myocardial infarction (AMI) is controversial. We investigated whether hyperuricemia was linked with long-term mortality in patients with AMI who underwent percutaneous coronary intervention (PCI).

Methods

Patients with AMI who received PCI were consecutively included. The definition of preprocedural hyperuricemia was a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. All-cause mortality was assessed during 2.3-year median follow up period.

Results

One thousand and five patients with AMI undergoing PCI were enrolled in a single center study, 307 (30.5%) patients had hyperuricemia. After adjusting for potential confounding factors, the multivariable analysis indicated that preprocedural hyperuricemia was related to an increased risk of all-cause mortality during the 2.3-year follow-up (HR: 1.97; 95% CI: 1.11–3.49; P=0.019).

Conclusions

Preprocedural hyperuricemia, independently from chronic kidney disease (CKD), is a significant and independent predictor of long-term mortality for patients with AMI who underwent PCI.

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Author and article information

Journal

Journal ID (nlm-ta): Ann Transl Med

Journal ID (iso-abbrev): Ann Transl Med

Journal ID (publisher-id): ATM

Title: Annals of Translational Medicine

Publisher: AME Publishing Company

ISSN (Print): 2305-5839

ISSN (Electronic): 2305-5847

Publication date (Print and electronic): November 2019

Publication date (Print): November 2019

Volume: 7

Issue: 22

Electronic Location Identifier: 636

Affiliations

[1 ]Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences , Guangzhou 510080, China;

[2 ]Department of Cardiology, Guangdong provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences , Guangzhou 510080, China;

[3 ]Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, Shenzhen 518000, China;

[4 ]Department of Cardiology, Panzhihua Central Hospital, Panzhihua 617000, China,

Author notes

Contributions: (I) Conception and design: W Guo; (II) Administrative support: Y Liu, L Rao, L Zhang; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: W Guo, Y Liu, S Chen, J Liu, L Rao, L Zhang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

[#]

These authors contributed equally to this work.

Correspondence to: Yong Liu, MD, PhD. Department of Cardiology, Guangdong provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Lifen Rao, MD; Li Zhang, MD. Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Email: liuyong2099@ 123456126.com ; raodoctor@ 123456126.com ; gdgdavid@ 123456163.com .

Article

Accession ID: PMC6944565 Pmcid ID: PMC6944565 Pmc-uid ID: 6944565 Publisher ID: atm-07-22-636

DOI: 10.21037/atm.2019.10.110

PMC ID: 6944565

PubMed ID: 31930037

SO-VID: 1f9eeacc-a93c-42b2-b9f1-454ea958d241

History

Date received : 08 October 2019

Date accepted : 16 October 2019

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