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Immunostimulant Agents from Andrographis paniculata
July 1993
July 1993
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Abstract
EtOH extract and purified diterpene andrographolides of Andrographis paniculata (Acanthaceae)
induced significant stimulation of antibody and delayed type hypersensitivity (DTH)
response to sheep red blood cells (SRBC) in mice. The plant preparations also stimulated
nonspecific immune response of the animals measured in terms of macrophage migration
index (MMI) phagocytosis of 14C-leucine labelled Escherichia coli and proliferation
of splenic lymphocytes. The stimulation of both antigen specific and nonspecific immune
response was, however, of lower order with andrographolide than with the EtOH extract,
suggesting thereby that substance(s) other than andrographolide present in the extract
may also be contributing towards immunostimulation.