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      Efeito colateral da flunarizina: parkinsonismo grave Translated title: Adverse reaction to flunarizine: severe parkinsonism

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      Arquivos de Neuro-Psiquiatria
      Academia Brasileira de Neurologia - ABNEURO

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          Abstract

          O autor relata oito casos de pacientes com parkinsonismo ou síndrome de Parkinson graves, limitantes para a vida produtiva, com desaparecimento dos sintomas após a suspensão da flunarizina, exceto num caso, no qual apenas houve melhora. Objetiva claramente alertar para este efeito colateral, suspeitando que deva ser grande o número de pacientes tratados como apresentando doença de Parkinson, em uso da flunarizina.

          Translated abstract

          The author describes the cases of eight patients with severe Parkinson syndrome who had their symptoms vanished after suspension of flunarizine, except for one case whose symptoms remitted partially. The author intention is clearly to alert to this unfavorable reaction, since there may be a lot of patients treated like having Parkinson disease in use of flunarizine.

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          Flunarizine- and cinnarizine-induced extrapyramidal reactions.

          Cinnarizine and flunarizine are selective calcium blockers that have been used to treat and prevent vertigo. We studied 15 patients who had extrapyramidal syndromes after taking these drugs. Eleven patients had parkinsonism, one with persistent akathisia as well; one had an orofacial tremor; one, acute akathisia alone; and one an acute dystonic reaction. All but one improved when the drug therapy was discontinued. Seven patients were also depressed during treatment. Cinnarizine and flunarizine must therefore be added to the list of potentially risky drugs known to induce extrapyramidal reactions and depression.
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            The pharmacology of calcium channel antagonists: a novel class of anti-migraine agents?

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              Neuroendocrinological evidence of an anti-dopaminergic effect of flunarizine.

              The effect of a one month treatment with flunarizine (5 mg/day) on pituitary responsiveness to gonadotrophin-releasing hormone (GnRH), thyrotrophin-releasing hormone (TRH) and arginine infusion was assessed in 17 adolescents (11 M, 6 F) treated with the drug to prevent migraine attacks. Basal prolactin concentrations as well as the prolactin response to TRH were significantly (p less than 0.05) increased after flunarizine treatment. Flunarizine had no effect on the folliclestimulating and luteinising hormone response to GnRH stimulation, growth hormone response to arginine infusion or thyrotrophin response to TRH stimulation. Our data suggest that flunarizine may interfere with the hypothalamic-pituitary-prolactin axis decreasing dopaminergic inhibitory tonus.
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                Author and article information

                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo, SP, Brazil )
                0004-282X
                1678-4227
                September 1989
                : 47
                : 3
                : 352-354
                Affiliations
                [01] orgnamePontifícia Universidade Católica do Rio Grande do Sul
                Article
                S0004-282X1989000300017 S0004-282X(89)04700317
                1f36b77e-d717-47af-8f27-b28a4ac08f84

                This work is licensed under a Creative Commons Attribution 4.0 International License.

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                Figures: 0, Tables: 0, Equations: 0, References: 5, Pages: 3
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