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      How to quantify exposure to traumatic stress? Reliability and predictive validity of measures for cumulative trauma exposure in a post-conflict population

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          Abstract

          Background

          While studies with survivors of single traumatic experiences highlight individual response variation following trauma, research from conflict regions shows that almost everyone develops posttraumatic stress disorder (PTSD) if trauma exposure reaches extreme levels. Therefore, evaluating the effects of cumulative trauma exposure is of utmost importance in studies investigating risk factors for PTSD. Yet, little research has been devoted to evaluate how this important environmental risk factor can be best quantified.

          Methods

          We investigated the retest reliability and predictive validity of different trauma measures in a sample of 227 Ugandan rebel war survivors. Trauma exposure was modeled as the number of traumatic event types experienced or as a score considering traumatic event frequencies. In addition, we investigated whether age at trauma exposure can be reliably measured and improves PTSD risk prediction.

          Results

          All trauma measures showed good reliability. While prediction of lifetime PTSD was most accurate from the number of different traumatic event types experienced, inclusion of event frequencies slightly improved the prediction of current PTSD.

          Conclusions

          As assessing the number of traumatic events experienced is the least stressful and time-consuming assessment and leads to the best prediction of lifetime PTSD, we recommend this measure for research on PTSD etiology.

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          Most cited references40

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            Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.

            Although the fact that genetic predisposition and environmental exposures interact to shape development and function of the human brain and, ultimately, the risk of psychiatric disorders has drawn wide interest, the corresponding molecular mechanisms have not yet been elucidated. We found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in the FK506 binding protein 5 (FKBP5) gene, an important regulator of the stress hormone system, increased the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma-dependent DNA demethylation in functional glucocorticoid response elements of FKBP5. This demethylation was linked to increased stress-dependent gene transcription followed by a long-term dysregulation of the stress hormone system and a global effect on the function of immune cells and brain areas associated with stress regulation. This identification of molecular mechanisms of genotype-directed long-term environmental reactivity will be useful for designing more effective treatment strategies for stress-related disorders.
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              Negative Binomial Regression

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                Author and article information

                Journal
                Eur J Psychotraumatol
                Eur J Psychotraumatol
                EJPT
                European Journal of Psychotraumatology
                Co-Action Publishing
                2000-8198
                2000-8066
                19 November 2015
                2015
                : 6
                : 10.3402/ejpt.v6.28306
                Affiliations
                [1 ]Clinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany
                [2 ]Vivo International, Allensbach, Germany
                [3 ]Clinical Psychology, University of Konstanz, Konstanz, Germany
                [4 ]SAP Switzerland AG, Tägerwilen, Switzerland
                Author notes
                [* ]Correspondence to: Sarah Wilker, Clinical & Biological Psychology, Institute of Psychology and Education, Ulm University, Albert-Einstein-Allee 47, DE-89069 Ulm, Germany, Email: sarah.wilker@ 123456uni-ulm.de

                Responsible Editor: Marianna Purgato, Johns Hopkins Bloomberg School of Public, USA.

                This paper is part of the Special Issue: Global mental health and trauma. More papers from this issue can be found at www.ejpt.net

                Article
                28306
                10.3402/ejpt.v6.28306
                4654773
                26589255
                1ebed19c-57db-422f-bf68-eb809905b5f5
                © 2015 Sarah Wilker et al.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format, and to remix, transform, and build upon the material, for any purpose, even commercially, under the condition that appropriate credit is given, that a link to the license is provided, and that you indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

                History
                : 21 April 2015
                : 10 July 2015
                : 21 July 2015
                Categories
                Special Issue: Global Mental Health and Trauma

                Clinical Psychology & Psychiatry
                cumulative trauma exposure,event list,reliability,predictive validity,posttraumatic stress disorder

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