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Bromocriptine in type 2 diabetes mellitus
review-article
Publication date (Print):
July 2011
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Abstract
Bromocriptine mesylate quick-release was approved by the Food and Drug Administration (FDA) in May 2009, for the treatment of type 2 diabetes. Bromocriptine is thought to act on the circadian neuronal activities in the hypothalamus, to reset an abnormally elevated hypothalamic drive for increased plasma glucose, free fatty acids, and triglycerides in insulin-resistant patients. Randomized controlled trials have shown that bromocriptine-QR lowers glycated hemoglobin by 0.4 – 0.8% either as monotherapy or in combination with other anti-diabetes medications. The doses used to treat diabetes (up to 4.8 mg daily) are much lower than those used to treat Parkinson's disease, and apart from nausea, the drug is well-tolerated. The novel mechanism of action, good side effect profile, and its effects to reduce cardiovascular event rates make it an attractive option for the treatment of type 2 diabetes.
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Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes
Ralph A. DeFronzo (2011)
Bromocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes. Based on animal and human studies, timed bromocriptine administration within 2 h of awakening is believed to augment low hypothalamic dopamine levels and inhibit excessive sympathetic tone within the central nervous system (CNS), resulting in a reduction in postmeal plasma glucose levels due to enhanced suppression of hepatic glucose production. Bromocriptine has not been shown to augment insulin secretion or enhance insulin sensitivity in peripheral tissues (muscle). Addition of bromocriptine to poorly controlled type 2 diabetic patients treated with diet alone, metformin, sulfonylureas, or thiazolidinediones produces a 0.5–0.7 decrement in HbA1c. Bromocriptine also reduces fasting and postmeal plasma free fatty acid (FFA) and triglyceride levels. In a 52 double-blind, placebo-controlled study in type 2 diabetic patients, bromocriptine reduced the composite cardiovascular end point by 40%. The mechanism of the drug’s beneficial effect on cardiovascular disease remains to be determined. Introduction Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance, impaired β-cell function, and multiple other metabolic/endocrine abnormalities (1). Because of its multifactorial pathogenesis, restoration of normoglycemia is difficult to achieve and requires multiple antidiabetic medications that have different mechanisms of action and can be used in combination to produce an additive effect (1,2). Therefore, the development of antidiabetic agents that have novel mechanisms of action and can be used in combination with currently approved medications for the treatment of type 2 diabetes is highly desirable. Type 2 diabetic patients are at high risk for atherosclerotic cardiovascular complications (3). Although hyperglycemia is a risk factor for coronary artery disease and stroke, it is a relatively weak risk factor compared with other more established risk factors such as dyslipidemia, hypertension, obesity, and the insulin resistance (metabolic) syndrome (4,5). However, even after correction of dyslipidemia, hypertension, and dysglycemia, type 2 diabetic patients still remain at high risk for atherosclerotic cardiovascular complications (6). Therefore, antidiabetic agents that not only improve glycemia but also reduce cardiovascular risk are desirable. Recently, timed-release bromocriptine (Cycloset), a sympatholytic dopamine D2 receptor agonist, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes. This centrally acting antidiabetic agent has a novel mechanism of action; reduces plasma glucose, triglyceride, and FFA levels; and in a prospective 1-year study reduced cardiovascular events. In this review, we will examine the mechanism of action, pharmacokinetic properties, glucose-lowering efficacy, potential antiatherogenic benefits, and safety of Cycloset. Mechanism of action Bromocriptine is unique in that it does not have a specific receptor that mediates its action on glucose and lipid metabolism. Rather, its effects are mediated via resetting of dopaminergic and sympathetic tone within the CNS (7). Because the human brain is not accessible to sampling, much of what we have learned about the mechanism of action of bromocriptine has been derived from animal studies. Mammalian species living in the wild have an incredible ability to alter their metabolism from the insulin-sensitive/glucose-tolerant state to the insulin-resistant/glucose-intolerant state at exactly the right time of the year to survive long periods when food is sparse (rev. in 7). During transition to the insulin-resistant state, basal lipolytic activity increases to spare glucose utilization by peripheral (muscle) tissues, fat oxidation becomes predominant, and hepatic glucose production and gluconeogenesis rise to supply glucose to the CNS during prolonged periods (seasons) of food deprivation. At the end of the season, animals revert back to their insulin-sensitive/glucose-tolerant state. Such seasonal metabolic changes are characteristic of all migrating birds and hibernating animals and are governed by changes in monoaminergic concentrations/activity in the suprachiasmatic nuclei (SCN) of the hypothalamus—the mammalian circadian pacemaker—and in the ventromedial hypothalamus (VMH) (7). These neurogenic and metabolic changes are consistent with the thrifty gene hypothesis (8), which proposes that conversion to the obese, insulin-resistant state during periods of inadequate food supply provides a survival advantage. It is noteworthy that development of the insulin-resistant state during these periods of seasonal change precisely mimics the type 2 diabetic state: insulin resistance in muscle and liver, accelerated hepatic glucose production/gluconeogenesis, hyperglycemia, adipocyte insulin resistance and increased lipolysis, enhanced fat oxidation, increased plasma FFA and triglyceride levels, and obesity. These changes also mimic those observed in people with the insulin resistance syndrome (5,9). A large body of evidence implicates endogenous dopaminergic and serotonergic rhythms in SCN and VMH in the transition from the insulin-sensitive to insulin-resistant state. The VMH has multiple connections with other hypothalamic nuclei and plays a pivotal role in modulating autonomic nervous system function, hormonal secretion, peripheral glucose/lipid metabolism, and feeding behavior (10–13). Within the VMH, multiple studies have documented that both serotonin and noradrenergic levels and activity are increased during the insulin-resistant state and decrease to normal with return to the insulin-sensitive state in animals that undergo seasonal changes in metabolism (14–19). Conversely, dopamine levels are low during the insulin-resistant state and increase to normal following return of the insulin-sensitive state (20,21). Further, selective destruction of dopaminergic neurons in the SCN causes severe insulin resistance (22), and animal models of nonseasonal obesity (i.e., ob/ob mouse [16], Zucker fatty rat [23], high energy–fed male Sprague-Dawley rats [24]) have reduced dopamine levels in VMH and lateral hypothalamic nuclei. Chronic infusion of norepinephrine and/or serotonin into the VMH of insulin-sensitive animals causes severe insulin resistance, glucose intolerance, and accelerated lipolysis in hamsters and rats (19,25). Conversely, systemic (20,26,27) and intracerebral (28) bromocriptine administration in insulin-resistant animals leads to a decrease in elevated VMH noradrenergic and serotonergic levels (measured in vivo by microdialysis) with a resultant decline in hepatic glucose production/gluconeogenesis, reduced adipose tissue lipolysis, and improved insulin sensitivity. Systemic bromocriptine also inhibits VMH responsiveness to norepinephrine (17), and, conversely, norepinephrine infusion into the VMH antagonizes the beneficial effect of bromocriptine on glucose tolerance and insulin sensitivity (29). Consistent with these observations in animals, systemic bromocriptine administration improves glycemic control and dyslipidemia without change in body weight in type 2 diabetic and obese nondiabetic humans (29–31). The proposed mechanism of action of bromocriptine to improve glucose tolerance is summarized in Fig. 1. Figure 1 Proposed mechanism of action of bromocriptine to improve glucose homeostasis and insulin sensitivity. HGP, hepatic glucose production; TG, triglyceride. In summary, in vertebrates circadian rhythms of target tissue response to insulin, i.e., lipolysis, hepatic glucose production, and muscle insulin sensitivity, are mediated via circadian rhythms within the CNS, i.e., the SCN and VMH, and act temporarily to regulate seasonal changes in metabolism and body fat stores/muscle mass. How do these circadian rhythms apply to humans and what are the implications for bromocriptine as a therapy for type 2 diabetes since humans do not manifest these pronounced circadian oscillations/seasonal changes in metabolism? As reviewed by Cincotta and colleagues (7,29,32), hypothalamic centers (SCN and VMH) that regulate these circadian rhythms not only receive photic inputs via the optic chiasm but also receive input from other centers throughout the CNS, neurogenic stimuli from peripheral tissues and gastrointestinal tract, hormonal signals, and signals from circulating metabolites. The net result after all of these inputs are integrated within the hypothalamus needs not to be circadian in nature. Nonetheless, interventions, such as bromocriptine, which alter monoamine neurotransmitter levels within these hypothalamic circadian centers, can exert significant effects on glucose and lipid metabolism. Pharmacokinetics and dose Following ingestion, Cycloset (bromocriptine mesylate) tablets are rapidly dissolved and absorbed within 30 min (29). When ingested on an empty stomach, the maximum plasma concentration is reached within 60 min. Absorption is delayed by food and peak plasma levels are achieved at ∼120 min in the fed state. There is extensive hepatic first-pass extraction and metabolism, and only 5–10% of the ingested dose reaches the systemic circulation (33–35). Ninety-eight percent of ingested bromocriptine is excreted via the biliary route with an elimination half-life of ∼6 h. Within the liver, bromocriptine is extensively metabolized by the cytochrome P450 system, specifically CYP3A4. There are some 20–30 metabolites, but their biologic activity is largely unknown. Cycloset differs from traditional bromocriptine formulations, such as Parlodel, in its quick release that provides peak concentrations within 60 min. There is no AB-rated equivalent for Cycloset. Cycloset comes as 0.8 mg tablets. The starting dose is 0.8–1.6 mg/day and can be titrated to a maximum of 4.6 mg/day. Cycloset is administered as a once daily dose within 2 h of awaking. Type 2 diabetic individuals are believed to have an early morning dip in dopaminergic tone, which leads to increased sympathetic activity (25). In vertebrate species circadian plasma prolactin levels closely parallel changes in hypothalamic levels of dopamine and insulin sensitivity (rev. in 7 and 32). In lean, normal glucose-tolerant insulin-sensitive humans, plasma prolactin concentrations peak at night during sleep. In contrast, obese insulin-resistant individuals have elevated (twofold) day time plasma prolactin levels (29), consistent with reduced dopaminergic tone (36). Administration of Cycloset within 2 h of awakening reduces the elevated prolactin levels (29,37,38) and is thought to restore dopaminergic activity, thereby reducing postprandial plasma glucose, triglyceride, and FFA concentrations without increasing plasma insulin levels (see subsequent discussion). Mechanism of action—human trials A number of phase 2 trials have been performed to examine the mechanism of action of Cycloset. In a small study of 12 nondiabetic obese hyperinsulinemic (≥20 μU/mL) subjects (38), bromocriptine (1.6 mg/day for 2 weeks) reduced the fasting and postprandial (standardized meals) glucose levels without change in body weight and with a decrease in both fasting and postprandial plasma insulin concentrations by ∼50% (Supplementary Fig. 1). In a similar study, 8 weeks of timed bromocriptine reduced day-long plasma glucose, triglyceride, and FFA levels without change in body weight and a small decrease in plasma insulin concentration in 13 nondiabetic obese women (Supplementary Fig. 2) (31). Insulin-stimulated glucose disposal, measured with the insulin suppression test, was not altered. Since the insulin suppression test primarily reflects insulin-mediated glucose disposal in muscle, the improvement in postprandial plasma glucose levels (31) most likely reflects enhanced suppression of hepatic glucose production by insulin, similar to what has been described in animals (26). However, to date, no study has examined hepatic glucose production following glucose ingestion or in response to a physiologic increase in plasma insulin concentration in man. The decline in postprandial plasma FFA and triglyceride concentrations (32) is similar to observations in animals (26,38). In a 16-week double-blind, placebo-controlled study in 22 obese type 2 diabetic subjects treated with Cycloset for 16 weeks, HbA1c declined by 1.2%, fasting plasma glucose by 54 mg/dL, and mean plasma glucose during oral glucose tolerance test by 46 mg/dL without change in plasma insulin concentration, body weight, or percent body fat (30) (Supplementary Fig. 3). During a two-step euglycemic-hyperinsulinemic clamp, there was no improvement in insulin sensitivity during the first, physiologic insulin clamp step (80 μU/mL), although maximally insulin-stimulated (377 μU/mL) glucose disposal was increased. These results are consistent with those observed with the insulin suppression test (31) and demonstrate that, within the physiologic range of hyperinsulinemia, Cycloset does not improve insulin action in muscle. During the first insulin clamp step, suppression of hepatic glucose production was not enhanced by Cycloset. However, the steady-state plasma insulin concentration, although physiologic for muscle, was far above that required for half-maximal suppression of hepatic glucose production, making it difficult to ascertain whether hepatic insulin sensitivity was enhanced by insulin. In a provocative study (39), insulin-treated type 2 diabetic subjects were randomized to placebo (n = 11) or Cycloset (n = 21) (4.8 mg/day) for 12 weeks. Compared with placebo, Cycloset reduced HbA1c by 0.7% and mean plasma glucose concentration (7 a.m. to 7 p.m.) by 8% without change in body weight. These results are consistent with an improvement in insulin sensitivity, although the site, i.e., liver versus muscle, remains to be defined. In a small (n = 17) double-blind, placebo-controlled study (38) in nondiabetic obese individuals with elevated diurnal prolactin levels (changes in plasma prolactin parallel seasonal changes in insulin sensitivity and glucose tolerance in vertebrates [7]), Cycloset (1.6–2.4 mg/day) plus a 25% calorie-restricted diet significantly reduced body weight and body fat content compared with placebo plus diet. However, in a larger (n = 387) placebo-controlled 24-week study, Cycloset plus diet failed to produce a greater weight loss than placebo plus diet in obese nondiabetic subjects (29). Of interest, a post hoc analysis revealed that obese subjects with elevated diurnal prolactin levels (who represented ∼1/4 of the group) lost more weight (5.7 vs. 3.0 kg) than subjects with a normal prolactin rhythm. Phase 3 efficacy trials Four phase 3 trials have evaluated the efficacy of Cycloset versus placebo in the treatment of type 2 diabetic patients (29,40,41). In all studies, Cycloset was administered in the morning within 2 h of awaking and individuals with atypical day-night work shifts were excluded from study. These four studies included 1) 24-week monotherapy trial (n = 159) (29), 2) two 24-week add-on to sulfonylurea trials (n = 494) (30), and 3) 52-week add-on to various oral antidiabetic agents trial (41) (Table 1). Results of these four studies consistently demonstrated a placebo-subtracted decline in HbA1c of 0.5–0.7%. Prior to randomization and after 6 months, type 2 diabetic subjects in the monotherapy and add-on to sulfonylurea studies (29) were admitted to the clinical research center for 12 h (7 a.m. to 7 p.m.) and received standardized meals for breakfast (0700 h), lunch (1200 h), and dinner (1700 h). Serum glucose, insulin, FFA, and triglyceride concentrations were measured prior to and at 1 and 2 h postmeal ingestion. Relative to placebo, Cycloset significantly reduced the fasting, postbreakfast, postlunch, and postdinner glucose concentrations (Supplementary Fig. 4) without change in serum insulin level or body weight. Cycloset also significantly reduced fasting and postmeal serum FFA and triglyceride concentrations (Supplementary Fig. 5). Table 1 Phase 3 Cycloset efficacy trials N Duration (months) Baseline HbA1c (%) Placebo-subtracted change in HbA1c (%) P Monotherapy 159 6 8.7 −0.56 7.5%) type 2 diabetic patients who were taking one to two oral hypoglycemic agents (OHAs) (41–43). Mean baseline HbA1c was 8.3%, mean age 58 years, mean BMI 33 kg/m2; 63% were male. In type 2 diabetic subjects who completed 24 weeks of treatment and who took ≥80% of their medication, the placebo-subtracted decrease in HbA1c ranged from 0.6 to 0.9% and was consistent in subjects failing any OHA, failing metformin ± OHA, failing metformin + sulfonylurea, and failing thiazolidinedione ± OHA (Supplementary Fig. 6) (41–43). Safety and tolerability In the Cycloset monotherapy and add-on to sulfonylurea trials (29), side effects that occurred more commonly in Cycloset versus placebo were nausea (26 vs. 5%), asthenia (15 vs. 8%), constipation (11 vs. 4%), dizziness (11 vs. 6%), and rhinitis (8 vs. 5%). In general, these side effects were mild and transient. Thirteen percent of Cycloset-treated subjects withdrew because of adverse events compared with 3–5% of placebo-treated subjects (P 5% and numerically were greater in the Cycloset group included nausea (32.2 vs. 7.6%), dizziness (14.8 vs. 9.2%), fatigue (13.9 vs. 6.7%), headache (11.4 vs. 8.3%), vomiting (8.1 vs. 3.1%), diarrhea (8.1 vs. 8.0%), and constipation (5.8 vs. 5.1%). The mechanism(s) via which timed bromocriptine reduces cardiovascular events in type 2 diabetic patients remains to be defined. In the cardiovascular safety trial (41), bromocriptine reduced HbA1c by 0.6% (P < 0.0001), blood pressure by 2/1 mmHg (P < 0.02), heart rate by 1 bpm (P = 0.02), and plasma triglyceride by 0.08 mmol/L (P = 0.02). However, these changes were modest and seem unlikely to explain the 40% decrease in composite cardiovascular outcome. Although not measured in the safety trial, reductions in postprandial FFA levels have been observed in other trials with bromocriptine (30,31). In animal studies, bromocriptine has been shown to attenuate the effect of CNS sympathetic overactivity on the vasculature (44,45), and a direct inhibitory effect of bromocriptine on mitogen-stimulated proliferation of rat vascular muscle cells and human aortic smooth muscle cells has been demonstrated in vitro (46). In the high fat–fed, spontaneously hypertensive rat (SHR)—an animal model of the insulin resistance syndrome and eNOS uncoupling—bromocriptine reduced pathologically elevated endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) levels (47). Uncoupled eNOS increases NAD[P]-H oxidase levels, resulting in generation of reactive oxygen species and decreased nitric oxide production, a potent vasodilator and antiatherogenic agent. All of these biochemical abnormalities were reversed in the aorta of bromocriptine-treated SHR, and aortic stiffness was markedly reduced. Thus, a number of biochemical/molecular abnormalities involved in the development of atherosclerosis, as well as multiple circulating cardiovascular risk factors (hyperglycemia, hypertriglyceridemia, and elevated FFA) and hypertension, improve with bromocriptine therapy. At present, it is unclear whether the salutatory effect of bromocriptine to reduce cardiovascular events (41) is related to the drug’s beneficial effect on any of these pathologic processes/atherosclerotic risk factors. Further mechanistic studies and a large, long-term prospective study will be required to establish the mechanism of action and cardiovascular protective benefit of bromocriptine therapy. Summary Both as monotherapy and in combination with other OHAs, timed bromocriptine (Cycloset) causes a 0.6–0.7% reduction in HbA1c and reduces plasma triglyceride and FFA concentrations in type 2 diabetic patients. In a 52-week safety study, Cycloset decreased the cardiovascular composite end point by 40%. Other advantages of Cycloset include absence of hypoglycemia since insulin secretion is not stimulated, weight neutrality, no need for dose adjustment in patients with moderate renal insufficiency, lack of edema and CHF, and good side effect profile. Supplementary Material Supplementary Data
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Bromocriptine: a novel approach to the treatment of type 2 diabetes.
Mary Lancaster, M. Matsuda, Y. Miyazaki … (2000)
In vertebrates, body fat stores and insulin action are controlled by the temporal interaction of circadian neuroendocrine oscillations. Bromocriptine modulates neurotransmitter action in the brain and has been shown to improve glucose tolerance and insulin resistance in animal models of obesity and diabetes. We studied the effect of a quick-release bromocriptine formulation on glucose homeostasis and insulin sensitivity in obese type 2 diabetic subjects. There were 22 obese subjects with type 2 diabetes randomized to receive a quick-release formulation of bromocriptine (n = 15) or placebo (n = 7) in a 16-week double-blind study. Subjects were prescribed a weight-maintaining diet to exclude any effect of changes in body weight on the primary outcome measurements. Fasting plasma glucose concentration and HbA(1c) were measured at 2- to 4-week intervals during treatment. Body composition (underwater weighing), body fat distribution (magnetic resonance imaging), oral glucose tolerance (oral glucose tolerance test [OGTT]), insulin-mediated glucose disposal, and endogenous glucose production (2-step euglycemic insulin clamp, 40 and 160 mU x min(-1) x m(-2)) were measured before and after treatment. No changes in body weight or body composition occurred during the study in either placebo- or bromocriptine-treated subjects. Bromocriptine significantly reduced HbA(1c) (from 8.7 to 8.1%, P = 0.009) and fasting plasma glucose (from 190 to 172 mg/dl, P = 0.02) levels, whereas these variables increased during placebo treatment (from 8.5 to 9.1%, NS, and from 187 to 223 mg/dl, P = 0.02, respectively). The differences in HbA(1c) (delta = 1.2%, P = 0.01) and fasting glucose (delta = 54 mg/dl, P < 0.001) levels between the bromocriptine and placebo group at 16 weeks were highly significant. The mean plasma glucose concentration during OGTT was significantly reduced by bromocriptine (from 294 to 272 mg/dl, P = 0.005), whereas it increased in the placebo group. No change in glucose disposal occurred during the first step of the insulin clamp in either the bromocriptine- or placebo-treated group. During the second insulin clamp step, bromocriptine improved total glucose disposal from 6.8 to 8.4 mg x min(-1) kg(-1) fat-free mass (FFM) (P = 0.01) and nonoxidative glucose disposal from 3.3 to 4.3 mg min(-1) x kg(-1) FFM (P < 0.05), whereas both of these variables deteriorated significantly (P < or = 0.02) in the placebo group. Bromocriptine improves glycemic control and glucose tolerance in obese type 2 diabetic patients. Both reductions in fasting and postprandial plasma glucose levels appear to contribute to the improvement in glucose tolerance. The bromocriptine-induced improvement in glycemic control is associated with enhanced maximally stimulated insulin-mediated glucose disposal.
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A review of the receptor-binding and pharmacokinetic properties of dopamine agonists.
Dopamine agonists (DAs), which can be categorized as ergot derived and non-ergot derived, are used in the treatment of Parkinson's disease. This review describes the pharmacologic and pharmacokinetic properties of selected DAs and relates these characteristics to clinical outcomes, with an emphasis on adverse events. Relevant articles were identified through a search of MEDLINE (to May 2006) using the terms dopamine agonists (or each individual drug name) and pbarmacokinetics, metabolism, drug-drug interaction, interactions, CYP450, fibrosis, valvular heart disease, tremor, clinical trials, reviews, and meta-analyses. Abstracts from recent sessions of the International Congress of Parkinson's Disease and Movement Disorders were also examined. Clinical studies with <20 patients overall or <10 patients per treatment group in the final analysis were excluded. All DAs that were graded at least possibly useful with respect to at least 3 of 4 items connected to the treatment/prevention of motor symptoms/complications in the most recent evidence-based medical review update were included. This resulted in a focus on the ergot-derived DAs bromocriptine, cabergoline, and pergolide, and the non-ergot-derived DAs pramipexole and ropinirole. Bromocriptine, cabergoline, pergolide, and ropinirole, but not pramipexole, have the potential for drug-drug interactions mediated by the cytochrome P450 (CYP) enzyme system. The occurrence of dyskinesia may be linked to stimulation of the dopamine D(1) receptor, for which cabergoline and pergolide have a similar and relatively high affinity; bromocriptine, pramipexole, and ropinirole have been associated with a lower risk of dyskinesias. The valvular heart disease (VHD) and pulmonary and retroperitoneal fibrosis seen with long-term use appear to represent a class effect of the ergot-derived DAs that may be related to stimulation of serotonin 5-HT(2B) (and possibly 5-HT(2A)) receptors. The incidence of valvular regurgitation was 31% to 47% with ergot-derived DAs, 10% with non-ergot-derived DAs, and 13% with controls. As reflected in the results of the clinical trials included in this review, dyskinesia associated with DA therapy may be linked to stimulation of the D(1) receptor. Fibrosis (including VHD) seemed to be a class effect of the ergot-derived DAs. Each of the DAs except pramipexole has the potential to interact with other drugs via the CYP enzyme system.
Author and article information
Journal
Journal ID (nlm-ta): Indian J Endocrinol Metab
Journal ID (publisher-id): IJEM
Title:
Indian Journal of Endocrinology and Metabolism
Publisher:
Medknow Publications
(India
)
ISSN
(Print):
2230-8210
ISSN
(Electronic):
2230-9500
Publication date
(Print):
July
2011
Volume: 15
Issue: Suppl1
Pages: S17-S24
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Author notes
Corresponding Author: Dr. Shivaprasad C., Department of Endocrinology, M. S. Ramaiah Hospital, Bangalore,
India. E-mail:
shvprsd.c@
123456gmail.com
Article
Publisher ID: IJEM-15-17DOI: 10.4103/2230-8210.83058
PMC ID: 3152192
PubMed ID: 21847449
SO-VID: 1e66556d-eccd-4744-b8a7-30b7c5a5c2ea
Copyright © © Indian Journal of Endocrinology and Metabolism
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This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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ScienceOpen disciplines: Endocrinology & Diabetes