Contributors
Timothy J. Henrich:
ORCID: http://orcid.org/0000-0002-6684-0622
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: ResourcesRole: SoftwareRole: SupervisionRole:
VisualizationRole: Writing – original draft
Hiroyu Hatano: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Oliver Bacon: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Writing – review
& editing
Louise E. Hogan:
ORCID: http://orcid.org/0000-0001-5526-954X
Role: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: VisualizationRole:
Writing – review & editing
Rachel Rutishauser: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review &
editing
Alison Hill:
ORCID: http://orcid.org/0000-0002-6583-3623
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SoftwareRole: Writing – original draftRole: Writing – review & editing
Mary F. Kearney: Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: SoftwareRole: Writing – review & editing
Elizabeth M. Anderson: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Susan P. Buchbinder:
ORCID: http://orcid.org/0000-0003-2404-0712
Role: InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole: Writing
– review & editing
Stephanie E. Cohen: Role: ConceptualizationRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing
– review & editing
Mohamed Abdel-Mohsen: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: ValidationRole: Writing – review & editing
Christopher W. Pohlmeyer: Role: Data curationRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing
– review & editing
Remi Fromentin:
ORCID: http://orcid.org/0000-0002-8153-1799
Role: Data curationRole: InvestigationRole: MethodologyRole: ResourcesRole: ValidationRole:
Writing – review & editing
Rebecca Hoh: Role: Data curationRole: Project administrationRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Albert Y. Liu:
ORCID: http://orcid.org/0000-0003-0320-823X
Role: InvestigationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Joseph M. McCune: Role: InvestigationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Jonathan Spindler: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SoftwareRole: Writing – review & editing
Kelly Metcalf-Pate:
ORCID: http://orcid.org/0000-0003-4799-4631
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SoftwareRole: Writing – review & editing
Kristen S. Hobbs:
ORCID: http://orcid.org/0000-0001-8912-7398
Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Cassandra Thanh: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Erica A. Gibson: Role: Data curationRole: InvestigationRole: MethodologyRole: Writing – review & editing
Daniel R. Kuritzkes: Role: ConceptualizationRole: ResourcesRole: SupervisionRole: Writing – review & editing
Robert F. Siliciano: Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Richard W. Price: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Douglas D. Richman:
ORCID: http://orcid.org/0000-0003-0962-9254
Role: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: Writing
– review & editing
Nicolas Chomont:
ORCID: http://orcid.org/0000-0001-9747-5018
Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: SupervisionRole: Writing – review & editing
Janet D. Siliciano:
ORCID: http://orcid.org/0000-0001-6712-3775
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: Writing – review & editing
John W. Mellors:
ORCID: http://orcid.org/0000-0002-3737-9742
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: Writing – review & editing
Steven A. Yukl:
ORCID: http://orcid.org/0000-0002-4578-9872
Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: ResourcesRole: Writing – review & editing
Joel N. Blankson:
ORCID: http://orcid.org/0000-0002-9683-8021
Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: ResourcesRole: Writing – original draftRole: Writing – review & editing
Teri Liegler: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ResourcesRole: SupervisionRole: Writing – review & editing
Steven G. Deeks:
ORCID: http://orcid.org/0000-0001-6371-747X
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
ResourcesRole: SupervisionRole: Writing – original draftRole: Writing – review & editing
Linda-Gail Bekker: Role: Academic Editor
Journal
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
7
November
2017
Publication date Collection:
November
2017
Volume: 14
Issue: 11
Electronic Location Identifier: e1002417
Affiliations
[1
]
Division of Experimental Medicine, University of California, San Francisco, California,
United States of America
[2
]
Division of HIV, Infectious Diseases and Global Medicine, University of California,
San Francisco, California, United States of America
[3
]
San Francisco Department of Public Health, San Francisco, California, United States
of America
[4
]
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United
States of America
[5
]
HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer
Institute, Frederick, Maryland, United States of America
[6
]
The Wistar Institute, Philadelphia, Pennsylvania, United States of America
[7
]
Center for AIDS Research, Department of Medicine, Johns Hopkins University School
of Medicine, Baltimore, Maryland, United States of America
[8
]
Centre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology,
Université de Montréal, Montreal, Quebec, Canada
[9
]
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts,
United States of America
[10
]
Harvard Medical School, Boston, Massachusetts, United States of America
[11
]
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States of America
[12
]
Howard Hughes Medical Institute, Baltimore, Maryland, United States of America
[13
]
Department of Neurology, University of California, San Francisco, California, United
States of America
[14
]
University of California San Diego, La Jolla, California, United States of America
[15
]
Veterans Affairs San Diego Healthcare System, San Diego, California, United States
of America
[16
]
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United
States of America
[17
]
San Francisco Veterans Affairs Medical Center, San Francisco, California, United States
of America
[18
]
University of California, San Francisco, California, Unites States of America
Desmond Tutu HIV Centre, SOUTH AFRICA
Author notes
I have read the journal's policy and the authors of this manuscript have the following
competing interests: AYL has led trials in which Gilead has donated study drug. SEC
was the protocol co-chair an a site principle investigator of the US PrEP demonstration
project for which Gilead donated study drug. JWM has share options in C0-Crystal,
Inc; is on the scientific advisory board for Gilead Sciences; and has received research
funding from Gilead Sciences, Janssen Pharmaceuticals, and Abbott Molecular. SGD declares
the research group has received external funding to support our research from ViiV,
Gilead, and Merck. He is also a guest editor for the
PLOS Medicine special issue on Advances in HIV Prevention, Treatment and Cure. DRK is a consultant,
research support and speaker for Gilead; a consultant for Janssen; a consultant, research
support and speaker for Merck; a consultant and research support for ViiV.
Author information
Article
Publisher ID:
PMEDICINE-D-17-02137
DOI: 10.1371/journal.pmed.1002417
PMC ID: 5675377
PubMed ID: 29112956
SO-VID: 1e57f3af-3bce-4e9a-ac32-41fcebffcf51
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 19
June
2017
Date
accepted
: 29
September
2017
Page count
Figures: 3,
Tables: 2,
Pages: 22
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100001117, amfAR, The Foundation for AIDS Research;
Award ID: 109301
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: Delaney AIDS Research Enterprise (DARE: AI096109 and AI127966)
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6371-747X
Steven G. Deeks
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R33 AI116205
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6684-0622
Timothy J. Henrich
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: K23 AI098480
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6684-0622
Timothy J. Henrich
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: UCSF/Gladstone Institute of Virology & Immunology CFAR (P30 AI027763)
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: K01 ODO18244
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4799-4631
Kelly Metcalf-Pate
Funded by: National Institutes of Health
Award ID: R01AI120024
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9683-8021
Joel N. Blankson
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01 DK108348-01
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4578-9872
Steven A. Yukl
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: Collaboratory for AIDS Research on Eradication (CARE; U19 AI096113 and 1UM1AI126619)
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: BEAT-HIV Delaney Collaboratory (1UM1Al126620)
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: UCSD CFAR (AI306214)
Funded by: funder-id http://dx.doi.org/10.13039/100000738, U.S. Department of Veterans Affairs;
Award ID: 1 IK2CX000520-01
Award Recipient
:
ORCID: http://orcid.org/0000-0002-4578-9872
Steven A. Yukl
Funded by: James B. Pendleton Charitable Trust (US)
Funded by: funder-id http://dx.doi.org/10.13039/100000054, National Cancer Institute;
Award ID: Itramural Funding
Funded by: Leidos Biomedical Research, Inc.
Award ID: subcontract 12XS547
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3737-9742
John W. Mellors
This research was supported as part of the amfAR Institute for HIV Cure Research (amfAR
109301), the Delaney AIDS Research Enterprise (DARE; AI096109 and A127966), NIH-NIAID
R33 (AI116205; TJH), and NIH-NIAID (AI098480; TJH). The SCOPE cohort was also supported
by the UCSF/Gladstone Institute of Virology & Immunology CFAR (P30 AI027763) and by
NIH ORIP (K01 OD018244, KMP), R01AI120024 (JNB), and 1R01DK108349-01 (SAY). This research
was also supported by the Collaboratory for AIDS Research on Eradication (CARE; U19
AI096113 and 1UM1AI126619), the BEAT-HIV Delaney Collaboratory (1UM1Al126620), the
UCSD CFAR (AI306214), the Department of Veterans Affairs (1 IK2CX000520-01, SAY),
the James B. Pendleton Charitable Trust, intramural funding to the National Cancer
Institute, and by Leidos Biomedical Research, Inc. subcontract 12XS547 (JWM). No funding
bodies had any role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Prophylaxis
Subject:
Pre-Exposure Prophylaxis
Subject:
Medicine and health sciences
Subject:
Infectious diseases
Subject:
Viral diseases
Subject:
HIV infections
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
RNA sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
RNA sequencing
Custom metadata