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      Development of Wunderlich syndrome following a Russell's viper bite.

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          Abstract

          Snakebite envenomation is a high priority neglected tropical disease that predominantly affects rural communities living in developing countries. Due to myriad of complications including coagulopathies, neurotoxicity, nephrotoxicity and local tissue destruction, treating snakebite victims is a major challenge for clinicians. Russell's viper (Daboia russelii) is one of the 'Big Four' venomous snakes in India, and it is responsible for the most snakebite-induced deaths and disabilities. Acute kidney injury occurs frequently following Russell's viper bites and it is a critical factor contributing to disabilities, deaths and excessive treatment costs. In addition to commonly observed envenomation effects, Russell's viper bites induce some rare complications such as priapism, sialolithiasis and splenic rupture. Here, we report a case of Wunderlich syndrome that developed in a 22-year-old male following a Russell's viper bite. The patient displayed severe coagulopathies, abdominal tenderness, and hypotension. Notably, a peri-nephric haematoma was identified through ultrasound and computerised tomographic imaging. The haemorrhage was successfully treated using angioembolisation, and the patient recovered without any difficulties. Although a clinical condition such as this is rare, it is important to create awareness among treating clinicians about its occurrence, diagnosis and clinical management.

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          Author and article information

          Journal
          Toxicon
          Toxicon : official journal of the International Society on Toxinology
          Elsevier BV
          1879-3150
          0041-0101
          Aug 2022
          : 215
          Affiliations
          [1 ] Manian Medical Centre, Erode, Tamil Nadu, India.
          [2 ] The Poison Control Center, Children's Hospital of Philadelphia, USA.
          [3 ] Toxiven Biotech Private Limited, Coimbatore, Tamil Nadu, India.
          [4 ] School of Pharmacy, University of Reading, UK.
          [5 ] Trichy SRM Medical College Hospital & Research Centre, Trichy, Tamil Nadu, India.
          [6 ] School of Biological Sciences, University of Reading, Reading, UK.
          [7 ] School of Pharmacy, University of Reading, UK. Electronic address: s.vaiyapuri@reading.ac.uk.
          Article
          S0041-0101(22)00187-8
          10.1016/j.toxicon.2022.06.004
          35691405
          1e0f20be-5104-4983-881d-f6d885147d21
          History

          Russell's viper,Snakebite envenomation,Wunderlich syndrome,peri-nephric haematoma,Acute kidney injury

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