The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential.

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Abstract

Zinc containing peptidases are widely distributed in nature and have important roles in many physiological processes. M4 family comprises numerous zinc-dependent metallopeptidases that hydrolyze peptide bonds. A large number of these enzymes are implicated as virulence factors of the microorganisms that produce them and are therefore potential drug targets. Some enzymes of the family are able to function at the extremes of temperatures, and some function in organic solvents. Thereby enzymes of the thermolysin family have an innovative potential for biotechnological applications.

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Journal

Journal ID (iso-abbrev): Chem Biol Drug Des

Title: Chemical biology & drug design

Publisher: Wiley

ISSN (Electronic): 1747-0285

ISSN (Print): 1747-0277

Publication date (Electronic): Jan 2009

Volume: 73

Issue: 1

Affiliations

[1 ] Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N-9037 Tromsø, Norway. adekoya@fagmed.uit.no

Article

Publisher Item ID: JPP757

DOI: 10.1111/j.1747-0285.2008.00757.x

PubMed ID: 19152630

SO-VID: 1df28f10-5575-4b4f-8498-eceb311a6c14

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