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Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial.
Paul Little
1 ,
Beth Stuart ,
Michael Moore ,
Samuel Coenen ,
Christopher C Butler ,
Maciek Godycki-Cwirko ,
Artur Mierzecki ,
Slawomir Chlabicz ,
Antoni Torres ,
Jordi Almirall ,
Mel Davies ,
Tom Schaberg ,
Sigvard Mölstad ,
Francesco Blasi ,
An De Sutter ,
Janko Kersnik ,
Helena Hupkova ,
Pia Touboul ,
Kerenza Hood ,
Mark Mullee ,
Gilly O'Reilly ,
Curt Brugman ,
Herman Goossens ,
Theo Verheij
Feb 2013
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Abstract
Lower-respiratory-tract infection is one of the most common acute illnesses managed in primary care. Few placebo-controlled studies of antibiotics have been done, and overall effectiveness (particularly in subgroups such as older people) is debated. We aimed to compare the benefits and harms of amoxicillin for acute lower-respiratory-tract infection with those of placebo both overall and in patients aged 60 years or older.