The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction.

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Abstract

Steroidal farnesoid X receptor (FXR) agonists demonstrated potent anti-fibrotic activities and lowered portal hypertension in experimental models. The impact of the novel non-steroidal and selective FXR agonist PX20606 on portal hypertension and fibrosis was explored in this study.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Apr 2017

Volume: 66

Issue: 4

Affiliations

[1 ] Div. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

[2 ] Phenex Pharmaceuticals, Waldhofer Strasse 104, 69123 Heidelberg, Germany.

[3 ] Vienna Medical Innovation Center (VMIC), Group Practice LABORS.at, Vienna, Austria.

[4 ] Synovo GmbH, Paul-Ehrlich-Str. 15, 72076 Tübingen, Germany.

[5 ] Dept. of Surgery, Medical University of Vienna, Vienna, Austria.

[6 ] Dept. of Pathology, Medical University of Vienna, Vienna, Austria.

[7 ] Dept. of Biomedical Research, Medical University of Vienna, Vienna, Austria.

[8 ] Div. of Gastroenterology and Hepatology, Dept. of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address: michael.trauner@meduniwien.ac.at.

Article

Publisher Item ID: S0168-8278(16)30710-3

DOI: 10.1016/j.jhep.2016.12.005

PubMed ID: 27993716

SO-VID: 1cc6a485-25d2-4b41-a080-6f694d964dcf

History

Keywords: Bacterial translocation,Cirrhosis,FXR agonist,Farnesoid X receptor,Fibrosis,Intestinal permeability,Mouse,PX20606,Portal hypertension,Rat

Data availability:

Keywords: Bacterial translocation, Cirrhosis, FXR agonist, Farnesoid X receptor, Fibrosis, Intestinal permeability, Mouse, PX20606, Portal hypertension, Rat

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