Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress, and the dysfunction of mitochondria. Although the mechanism of DOR is still unclear, recent studies have found that long non-coding RNA (lncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of granulosa cells in the ovary. LncRNAs participate in the occurrence of DOR by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. This review summarizes current research on lncRNAs associated with DOR and reveals the potential underlying mechanisms. The present study suggests that lncRNAs could be considered as prognostic markers and treatment targets for DOR.

Related collections

Most cited references 54

Record: found
Abstract: found
Article: found

Is Open Access

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

Iain M Dykes, Costanza Emanueli (2017)

Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.

0 comments Cited 281 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

H Kiyokawa, R D Kineman, K O Manova-Todorova … (1996)

Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodular hyperplasia in the intermediate lobe of the pituitary. However, increased growth occurs without an increase in the amounts of either growth hormone or IGF-I. In addition, female mice were infertile. Luteal cell differentiation is impaired, and a disordered estrus cycle is detected. These results reflect a disturbance of the hypothalamic-pituitary-ovarian axis. The phenotypes of these mice suggest that loss of p27 causes an alteration in cell proliferation that can lead to specific endocrine dysfunction.

0 comments Cited 152 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

The p53 family: guardians of maternal reproduction.

Arnold J. Levine, Richard Tomasini, Frank McKeon … (2011)

The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that affect both cancer and development. It is now emerging that these proteins also regulate maternal reproduction. Whereas p63 is important for maturation of the egg, p73 ensures normal mitosis in the developing blastocyst. p53 subsequently regulates implantation of the embryo through transcriptional control of leukaemia inhibitory factor. Elucidating the cell biological basis of how these factors regulate female fertility may lead to new approaches to the control of human maternal reproduction.

0 comments Cited 116 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Linjiang Song: URI : https://loop.frontiersin.org/people/954807/overview

Qinxiu Zhang: URI : https://loop.frontiersin.org/people/997344/overview

Shaomi Zhu: URI : https://loop.frontiersin.org/people/2004671/overview

Journal

Journal ID (nlm-ta): Front Genet

Journal ID (iso-abbrev): Front Genet

Journal ID (publisher-id): Front. Genet.

Title: Frontiers in Genetics

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-8021

Publication date (Electronic): 08 February 2023

Publication date Collection: 2023

Volume: 14

Electronic Location Identifier: 1056061

Affiliations

[1] ¹ School of Medical and Life Sciences/Affiliated Reproductive and Women-Children Hospital , Chengdu University of Traditional Chinese Medicine , Chengdu, Sichuan, China

[2] ² State Key Laboratory of Biotherapy , Sichuan University , Chengdu, China

Author notes

Edited by: Vivek Sharma, Birla Institute of Technology and Science, India

Reviewed by: Kequan Lin, Zhejiang University, China

Zhiqiang Wang, Guangxi University, China

Jingsi Duan, Zhejiang University, China

*Correspondence: Shaomi Zhu, zhumi1982@ 123456163.com

[ † ]

ORCID: Linjiang Song, orcid.org/0000-0002-0512-0410; Shaomi Zhu, orcid.org/0000-0003-2958-8875

This article was submitted to RNA, a section of the journal Frontiers in Genetics

Article

Publisher ID: 1056061

DOI: 10.3389/fgene.2023.1056061

PMC ID: 9944763

PubMed ID: 36845376

SO-VID: 1c93b3fd-75e6-4f66-ba11-cdda5a87421e

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 07 October 2022

Date accepted : 30 January 2023

Funding

Funded by: Sichuan Province Science and Technology Support Program , doi 10.13039/100012542;

Funded by: Chengdu University of Traditional Chinese Medicine , doi 10.13039/501100008402;

This study was supported by Key research and development projects of Sichuan Science and Technology Program of Sichuan Provence, China (Grant No. 2022YFS0251) and “Xinglin Scholar” hospital special project of Chengdu University of Traditional Chinese Medicine (No. 2020yky03).

Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve

Read this article at

Abstract

Related collections

RNA drug delivery

Most cited references 54

Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

The p53 family: guardians of maternal reproduction.

Author and article information

Contributors

Journal

Affiliations

Author notes

Article

History

Funding

Categories

Comments

Comment on this article

Similar content 366

Cited by 2