Coated Cotton Fabrics with Antibacterial and Anti-Inflammatory Silica Nanoparticles for Improving Wound Healing

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Abstract

Herein, we report the preparation of bifunctional silica nanoparticles by covalent attachment of both an anti-inflammatory drug (ibuprofen) and an antibiotic (levofloxacin or norfloxacin) through amide groups. We also describe the coating of cotton fabrics with silica nanoparticles containing both ibuprofen and norfloxacin moieties linked by amide groups by using a one-step coating procedure under ultrasonic conditions. The functionalized nanoparticles and cotton fabrics have been characterized using spectroscopic and microscopic techniques. The functionalized nanoparticles and textiles have been treated with model proteases for the in situ release of the drugs by the amide bond enzymatic cleavage. Topical dermal applications in medical bandages are expected, which favor wound healing.

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Most cited references 21

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Skin Acute Wound Healing: A Comprehensive Review

Luis Cañedo-Dorantes, Mara Cañedo-Ayala (2019)

Experimental work of the last two decades has revealed the general steps of the wound healing process. This complex network has been organized in three sequential and overlapping steps. The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury and send danger signals to the brain, to stop bleeding and start inflammation. The following target of the inflammatory phase, led by the peripheral blood mononuclear cells, is to eliminate the pathogens and clean the wound. Once this is completed, the inflammatory phase is resolved and homeostasis is restored. The aim of the proliferative phase, the second phase, is to repair wound damage and begin tissue remodeling. Fibroplasia, reepithelialization, angiogenesis, and peripheral nerve repair are the central actions of this phase. Lastly, the objective of the final phase is to complete tissue remodeling and restore skin integrity. This review provides present day information regarding the status of the participant cells, extracellular matrix, cytokines, chemokines, and growth factors, as well as their interactions with the microenvironment during the wound healing process.

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Mussel-inspired immobilization of zwitterionic silver nanoparticles toward antibacterial cotton gauze for promoting wound healing

Jun Xiang, Ruixin Zhu, Shiying Lang … (2021)

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Pharmacologic enhancement of wound healing.

Brian G Pierce, Thomas Mustoe (1994)

The field of pharmacologic modulation of soft tissue repair is in its infancy. Although the soluble, cellular, and insoluble mediators that govern repair have not been elucidated, the application of pharmacologic concentrations of purified polypeptide growth factors, cytokines, and matrix molecules has nonetheless resulted in the acceleration of normal repair and the reversal of deficient repair in a wide variety of dermal wound models in animals. However, early clinical results using these factors have been less than encouraging, and their potential roles in the armamentarium of chronic wound therapies remain to be established.

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Author and article information

Journal

Journal ID (nlm-ta): ACS Appl Mater Interfaces

Journal ID (iso-abbrev): ACS Appl Mater Interfaces

Journal ID (publisher-id): am

Journal ID (coden): aamick

Title: ACS Applied Materials & Interfaces

Publisher: American Chemical Society

ISSN (Print): 1944-8244

ISSN (Electronic): 1944-8252

Publication date (Electronic): 12 March 2024

Publication date Collection: 27 March 2024

Volume: 16

Issue: 12

Pages: 14595-14604

Affiliations

[† ]Department of Chemistry and Centro de Innovación en Química Avanzada (ORFEO−CINQA), Universitat Autònoma de Barcelona , Cerdanyola del Vallès, 08193 Barcelona, Spain

[‡ ]Departament de Biología Cel.lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona , Cerdanyola del Vallès, 08193 Barcelona, Spain

Author notes

[* ]Email: roser.pleixats@ 123456uab.cat .

[* ]Email: adelina.vallribera@ 123456uab.es .

Author information

Albert Granados https://orcid.org/0000-0002-5362-5966

Carolina Gimbert-Suriñach https://orcid.org/0000-0002-4412-7607

Roser Pleixats https://orcid.org/0000-0003-2544-732X

Adelina Vallribera https://orcid.org/0000-0002-6452-4589

Article

DOI: 10.1021/acsami.4c00383

PMC ID: 10982928

PubMed ID: 38469717

SO-VID: 1c450c4c-1e2b-4c0b-8729-c7fc15698404

License:

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained ( https://creativecommons.org/licenses/by/4.0/).

History

Date received : 08 January 2024

Date accepted : 29 February 2024

Date revision received : 29 February 2024