For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
22
views
71
references
 Top references
cited by
19
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      309
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Advances in photosensitizer-related design for photodynamic therapy

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Photodynamic therapy (PDT) is highly effective in treating tumors located near body surface, offering strong tumor suppression and low damage to normal tissue nearby. PDT is also effective for treating a number of other conditions. PDT not only provide a precise and selective method for the treatment of various diseases by itself, it can also be used in combination with other traditional therapies. Because PDT uses light as the unique targeting mechanism, it has simpler and more direct targeting capability than traditional therapies. The core material of a PDT system is the photosensitizer which converts light energy to therapeutic factors/substances. Different photosensitizers have their distinct characteristics, leading to different advantages and disadvantages. These could be enhanced or compensated by using proper PDT system. Therefore, the selected type of photosensitizer would heavily influence the overall design of a PDT system. In this article, we evaluated major types of inorganic and organic PDT photosensitizers, and discussed future research directions in the field.

          Graphical abstract

          Related collections

          Most cited references71

          • Record: found
          • Abstract: found
          • Article: not found

          Photodynamic therapy – mechanisms, photosensitizers and combinations

          Krzysztof Kotowski, Olga Michel, Dawid Przystupski … (2018)
          Photodynamic therapy (PDT) is a modern and non-invasive form of therapy, used in the treatment of non-oncological diseases as well as cancers of various types and locations. It is based on the local or systemic application of a photosensitive compound - the photosensitizer, which is accumulated in pathological tissues. The photosensitizer molecules absorb the light of the appropriate wavelength, initiating the activation processes leading to the selective destruction of the inappropriate cells. The photocytotoxic reactions occur only within the pathological tissues, in the area of photosensitizer distribution, enabling selective destruction. Over the last decade, a significant acceleration in the development of nanotechnology has been observed. The combination of photosensitizers with nanomaterials can improve the photodynamic therapy efficiency and eliminate its side effects as well. The use of nanoparticles enables achievement a targeted method which is focused on specific receptors, and, as a result, increases the selectivity of the photodynamic therapy. The object of this review is the anticancer application of PDT, its advantages and possible modifications to potentiate its effects.
          Article 0 comments Cited 471 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Photosensitizers for Photodynamic Therapy

            Minhuan Lan, Shaojing Zhao, Weimin Liu … (2019)
            As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2 ). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.
            Article 0 comments Cited 231 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Recent progress in drug delivery

              Chong Li, Jiancheng Wang, Yiguang Wang … (2019)
              Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells and subcellular organs for drug release and absorption through a variety of drug carriers. Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility, drug aggregation, low bioavailability, poor biodistribution, lack of selectivity, or to reduce the side effects of therapeutic drugs. During 2015–2018, significant progress in the research on drug delivery systems has been achieved along with advances in related fields, such as pharmaceutical sciences, material sciences and biomedical sciences. This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples. It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
              Article 0 comments Cited 230 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Zhenmi Liu
                Journal
                Journal ID (nlm-ta): Asian J Pharm Sci
                Journal ID (iso-abbrev): Asian J Pharm Sci
                Title: Asian Journal of Pharmaceutical Sciences
                Publisher: Shenyang Pharmaceutical University
                ISSN (Print): 1818-0876
                ISSN (Electronic): 2221-285X
                Publication date PMC-release: 02 May 2021
                Publication date (Print): November 2021
                Publication date (Electronic): 02 May 2021
                Volume: 16
                Issue: 6
                Pages: 668-686
                Affiliations
                [a ]College of Polymer Science and Engineering, Sichuan University, Chengdu 610015, China
                [b ]West China School of Pharmacy, Sichuan University, Chengdu 610041, China
                [c ]West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China
                Author notes
                [* ]Corresponding author. zhenmiliu@ 123456scu.edu.cn
                Article
                Publisher Item ID: S1818-0876(21)00030-1
                DOI: 10.1016/j.ajps.2020.12.003
                PMC ID: 8737425
                PubMed ID: 35027948
                SO-VID: 1c04a310-4a30-498c-8565-54a446db4cb2
                Copyright © © 2021 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 23 September 2020
                Date revision received : 8 December 2020
                Date accepted : 23 December 2020
                Categories
                Subject: Review

                Keywords: photodynamic therapy,photosensitizer,tumour treatment,combination therapy,porphyrin
                Data availability:
                Keywords: photodynamic therapy, photosensitizer, tumour treatment, combination therapy, porphyrin

                Comments

                Comment on this article

                scite_

                Similar content309

                See all similar

                Cited by19

                See all cited by

                Most referenced authors949

                See all reference authors