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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
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Abstract
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL
5491. It was isolated from the mycelium by solvent extraction, purified by silica
gel column chromatography and crystallized as a colorless solid which melts at 183
approximately to 185 degrees C and has the empirical formula C56H89NO14. From its
characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene.
It is highly active against various Candida species, especially Candida albicans.
Its activity is compared with that of amphotericin B, candicidin and nystatin.