Rapid Development of a DNA Vaccine for Zika Virus

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Abstract

Zika virus (ZIKV) was identified as a cause of congenital disease during an explosive outbreak in the Americas and Caribbean in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of child-bearing age and their partners is imperative. Vaccination with DNA expressing the prM and E proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine-induced neutralizing activity that will prevent viremia following acute infection.

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Journal

Journal ID (nlm-journal-id): 0404511

Journal ID (pubmed-jr-id): 7473

Journal ID (nlm-ta): Science

Journal ID (iso-abbrev): Science

Title: Science (New York, N.Y.)

ISSN (Print): 0036-8075

ISSN (Electronic): 1095-9203

Publication date Nihms-submitted: 3 February 2017

Publication date (Electronic): 22 September 2016

Publication date (Print): 14 October 2016

Publication date PMC-release: 14 April 2017

Volume: 354

Issue: 6309

Pages: 237-240

Affiliations

[1 ]Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

[2 ]Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

[3 ]Federal University of Rio de Janeiro (UFRJ), COPPE, Chemical Engineering Program, Rio de Janeiro, RJ, Brazil

[4 ]Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA

[5 ]Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

[6 ]Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

[7 ]Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA

[8 ]Bioqual, Rockville, MD 20852, USA

[9 ]Translational Medicine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA

[10 ]Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA

[11 ]Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20852, USA

Author notes

[*]

equal contribution;

[†]

co-communicating

Article

Accession ID: PMC5304212 Pmcid ID: PMC5304212 Pmc-uid ID: 5304212 Manuscript ID: nihpa842100

DOI: 10.1126/science.aai9137

PMC ID: 5304212

PubMed ID: 27708058

SO-VID: 1ba86c0d-ce22-4d0e-ae28-8cebae66ed0c

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