Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts.

Lu, Jiamei; Shi, Jianhua; Li, Manxiang; Gui, Baosong; Fu, Rongguo; Yao, Ganglian; Duan, Zhaoyang; Lv, Zhian; Yang, Yanyan; Chen, Zhao; Jia, Lining; Tian, Lifang

doi:10.1016/j.lfs.2015.01.042

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Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts.

Author(s): Jiamei Lu ¹ , Jianhua Shi ² , Manxiang Li ³ , Baosong Gui ⁴ , Rongguo Fu ¹ , Ganglian Yao ¹ , Zhaoyang Duan ¹ , Zhian Lv ¹ , Yanyan Yang ¹ , Zhao Chen ¹ , Lining Jia ¹ , Lifang Tian ¹

Publication date (Electronic): Apr 15 2015

Journal: Life sciences

Publisher: Elsevier BV

Keywords: AMPK (PubChem CID: 16760291), Adenosine monophosphate-activated protein kinase (AMPK), Collagen, Connective tissue growth factor (CTGF), Renal fibroblasts, TGF-β1 (PubChem CID: 56842206), Transforming growth factor beta 1 (TGF-β1)

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Abstract

To clarify whether activation of adenosine monophosphate-activated protein kinase (AMPK) by metformin inhibits transforming growth factor beta (TGF-β)-induced collagen production in primary cultured mouse renal fibroblasts and further to address the molecular mechanisms.

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Journal ID (iso-abbrev): Life Sci.

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Apr 15 2015

Volume: 127

Affiliations

[1 ] Department of Nephrology Diseases, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.

[2 ] Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China.

[3 ] Department of Respiratory Diseases, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.

[4 ] Department of Nephrology Diseases, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China. Electronic address: lu-jia1980@163.com.

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Publisher Item ID: S0024-3205(15)00114-9

DOI: 10.1016/j.lfs.2015.01.042

PubMed ID: 25744403

SO-VID: 1b56ddc0-ba97-480f-8a6b-9569626fed7b

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Keywords: AMPK (PubChem CID: 16760291),Adenosine monophosphate-activated protein kinase (AMPK),Collagen,Connective tissue growth factor (CTGF),Renal fibroblasts,TGF-β1 (PubChem CID: 56842206),Transforming growth factor beta 1 (TGF-β1)

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts.

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