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      Nanostructured lipid matrices for improved microencapsulation of drugs

      Author(s): , ,
      Publication date Created:
      Publication date (Print):
      Journal: International Journal of Pharmaceutics
      Publisher: Elsevier BV

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          Abstract

          At the beginning of the nineties solid lipid nanoparticles (SLN) have been introduced as a novel nanoparticulate delivery system produced from solid lipids. Potential problems associated with SLN such as limited drug loading capacity, adjustment of drug release profile and potential drug expulsion during storage are avoided or minimised by the new generation, the nanostructured lipid carriers (NLC). NLC are produced by mixing solid lipids with spatially incompatible lipids leading to special structures of the lipid matrix, i.e. three types of NLC: (I) the imperfect structured type, (II) the structureless type and (III) the multiple type. A special preparation process-applicable to NLC but also SLN-allows the production of highly concentrated particle dispersions (>30-95%). Potential applications as drug delivery system are described.

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          Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art

          R Müller (2000)
          Article 0 comments Cited 315 times – based on 0 reviews     Review now
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            Solid lipid nanoparticles: production, characterization and applications.

            W Mehnert (2001)
            Solid lipid nanoparticles (SLN) have attracted increasing attention during recent years. This paper presents an overview about the selection of the ingredients, different ways of SLN production and SLN applications. Aspects of SLN stability and possibilities of SLN stabilization by lyophilization and spray drying are discussed. Special attention is paid to the relation between drug incorporation and the complexity of SLN dispersions, which includes the presence of alternative colloidal structures (liposomes, micelles, drug nanosuspensions, mixed micelles, liquid crystals) and the physical state of the lipid (supercooled melts, different lipid modifications). Appropriate analytical methods are needed for the characterization of SLN. The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed.
            Article 0 comments Cited 226 times – based on 0 reviews     Review now
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              Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.

              V Jenning, M Schafer-Korting, S. Gohla (2000)
              Burst release as well as sustained release has been reported for SLN suspensions. For dermal application, both features are of interest. Burst release can be useful to improve the penetration of a drug. Sustained release becomes important with active ingredients that are irritating at high concentrations or to supply the skin over a prolonged period of time with a drug. Glyceryl behenate SLN were loaded with vitamin A and the release profiles were studied. Franz diffusion cells were used to assess the release kinetic over a period of 24 h. Within the first 6 h retinol SLN displayed controlled release. After longer periods (12-24 h) the release rate increased and even exceeded the release rate of comparable nanoemulsions. Pure SLN dispersions are characterised by low viscosity. In contrast to membranous vesicles, SLN can also be stably incorporated in convenient topical dosage forms like hydrogels or creams. In the Franz diffusion cell these preparations showed a controlled release over 12-18 h. Similar to SLN dispersions an increase in release rate over a 24-h period was found. A good correlation between polymorphic transitions and increased drug release was observed in this study. Sustained release was often related to the metastable beta' polymorph. Drug expulsion is explained by a reduction of amorphous regions in the carrier lattice due to a beta'-->beta(i) polymorphic transition. This transformation can be controlled with surfactant mixtures or, in the case of the hydrogel and oil/water cream, with humectants or gelling agents. Thus, the release rate for the topical route of application is adjustable.
              Article 0 comments Cited 75 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: International Journal of Pharmaceutics
                Abbreviated Title: International Journal of Pharmaceutics
                Publisher: Elsevier BV
                ISSN (Print): 03785173
                Publication date Created: August 2002
                Publication date (Print): August 2002
                Volume: 242
                Issue: 1-2
                Pages: 121-128
                Article
                DOI: 10.1016/S0378-5173(02)00180-1
                PubMed ID: 12176234
                SO-VID: 1b410583-90ce-41b8-8c8e-dbda1fc94f98
                Copyright © © 2002
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                https://www.elsevier.com/tdm/userlicense/1.0/

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