Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA.

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Abstract

Circular RNAs (circRNAs) are noncoding RNAs generated by back splicing. Back splicing has been considered a rare event, but recent studies suggest that circRNAs are widely expressed. However, the expression, regulation, and function of circRNAs in vascular cells is still unknown.

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Author and article information

Journal

Journal ID (iso-abbrev): Circ. Res.

Title: Circulation research

ISSN (Electronic): 1524-4571

ISSN (Print): 0009-7330

Publication date (Electronic): Oct 23 2015

Volume: 117

Issue: 10

Affiliations

[1 ] From the Institute for Cardiovascular Regeneration, Center for Molecular Medicine, University Frankfurt, Frankfurt, Germany (J.-N.B., N.J., A.W.H., R.A.B., K.S., D.J., S.U., S.D.); Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch, Germany (W.C.); Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Frankfurt, Germany (K.S., A.M.Z.); and German Center for Cardiovascular Research (DZHK) (J.-N.B., N.J., W.C., R.A.B., K.S., D.J., A.M.Z., S.U., S.D.).

[2 ] From the Institute for Cardiovascular Regeneration, Center for Molecular Medicine, University Frankfurt, Frankfurt, Germany (J.-N.B., N.J., A.W.H., R.A.B., K.S., D.J., S.U., S.D.); Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin-Buch, Germany (W.C.); Department of Cardiology, Internal Medicine III, Goethe-University Hospital, Frankfurt, Germany (K.S., A.M.Z.); and German Center for Cardiovascular Research (DZHK) (J.-N.B., N.J., W.C., R.A.B., K.S., D.J., A.M.Z., S.U., S.D.). Dimmeler@em.uni-frankfurt.de.

Article

Publisher Item ID: CIRCRESAHA.115.306319

DOI: 10.1161/CIRCRESAHA.115.306319

PubMed ID: 26377962

SO-VID: 1b0ca22d-00ef-4de9-9825-ca31096952bc

History

Keywords: back-splicing,circRNAs,circular RNA,endothelial cells,hypoxia

Data availability:

Keywords: back-splicing, circRNAs, circular RNA, endothelial cells, hypoxia

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