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Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid
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Abstract
The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating
bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA), a promising
drug for the treatment of non-alcoholic steatohepatitis (NASH) and type 2 diabetes,
activates FXR. Mouse studies demonstrated that FXR activation by OCA alters hepatic
expression of many genes. However, no data are available on the effects of OCA in
the human liver. Here we generated gene expression profiles in human precision cut
liver slices (hPCLS) after treatment with OCA.
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