Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.

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Abstract

Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. The understanding of postischemic inflammation is very limited. The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model.

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Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): May 2009

Volume: 40

Issue: 5

Affiliations

[1 ] Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. m.gelderblom@uke.uni-hamburg.de.

Article

Publisher Item ID: STROKEAHA.108.534503

DOI: 10.1161/STROKEAHA.108.534503

PubMed ID: 19265055

SO-VID: 17ef4fb8-bca8-4122-a4cb-3792020bff6d

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