For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
45
views
153
references
 Top references
cited by
148
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      2,279
      similar
       All similar
      • Record: found
      • Abstract: not found
      • Article: not found

      22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

      Author(s): , ,
      Publication date Created:
      Publication date (Print):
      Journal: Nature Reviews Neuroscience
      Publisher: Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders.

          Related collections

          Most cited references153

          • Record: found
          • Abstract: not found
          • Article: not found

          The attention system of the human brain.

          Michael I. Posner, Steven E. Petersen (1990)
          Article 0 comments Cited 1123 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Neuronal synchrony: a versatile code for the definition of relations?

            W. Singer (1999)
            Article 0 comments Cited 554 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A brain-specific microRNA regulates dendritic spine development.

              Gerhard M Schratt, Fabian Tuebing, Elizabeth Nigh … (2006)
              MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of microRNAs have been isolated from the mammalian brain, neither the specific microRNAs that regulate synapse function nor their target mRNAs have been identified. Here we show that a brain-specific microRNA, miR-134, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines--postsynaptic sites of excitatory synaptic transmission. This effect is mediated by miR-134 inhibition of the translation of an mRNA encoding a protein kinase, Limk1, that controls spine development. Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity.
              Article 0 comments Cited 485 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Title: Nature Reviews Neuroscience
                Abbreviated Title: Nat Rev Neurosci
                Publisher: Springer Science and Business Media LLC
                ISSN (Print): 1471-003X
                ISSN (Electronic): 1471-0048
                Publication date Created: June 2010
                Publication date (Print): June 2010
                Volume: 11
                Issue: 6
                Pages: 402-416
                Article
                DOI: 10.1038/nrn2841
                PMC ID: 2977984
                PubMed ID: 20485365
                SO-VID: 17d399ec-addb-4444-9423-483276003745
                Copyright © © 2010
                License:

                http://www.springer.com/tdm

                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content2,279

                See all similar

                Cited by140

                See all cited by