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      Long non-coding RNA (lncRNA) CYTOR promotes hepatocellular carcinoma proliferation by targeting the microRNA-125a-5p/LASP1 axis

      research-article
      Author(s): a , b
      Publication date (Electronic, pub):
      Publication date (Electronic, collection):
      Journal: Bioengineered
      Publisher: Taylor & Francis
      Keywords: Lncrna cytor, hepatocellular carcinoma, miR-125a-5p, lasp1, proliferation, apoptosis

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          ABSTRACT

          This study investigated the function of long non-coding RNA (lncRNA) cytoskeleton regulator RNA (CYTOR) in hepatocellular carcinoma (HCC). In HCC, the expression of CYTOR and microRNA (miR)-125a-5p were measured by quantitative real-time PCR (qRT-PCR). The expression of actin skeletal protein 1 (LASP1) was evaluated by Western blot analysis. Flow cytometry assays, transwell assays, colony formation assay, and cell counting kit-8 (CCK-8) assay were used to evaluate the roles of miR-125a-5p and CYTOR in HCC cells. The target genes of CYTOR and miR-125a-5p were identified by bioinformatics analysis and Luciferase assay. CYTOR was upregulated in HCC cell lines, and knockdown of CYTOR inhibited HCC cell growth. MiR-125a-5p was downregulated in HCC cells and a target of CYTOR in regulating HCC progression. Furthermore, LASP1 was a downstream target of miR-125a-5p. Finally, CYTOR was found to be involved in HCC progression in vivo. CYTOR promotes HCC development by regulating the miR-125a-5p/LASP1 axis.

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          The immunology of hepatocellular carcinoma

          Marc Ringelhan, Mathias Heikenwalder, Dominik Pfister … (2018)
          In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for approximately 90% of primary liver cancers, arises almost exclusively in the setting of chronic inflammation. Irrespective of etiology, a typical sequence of chronic necroinflammation, compensatory liver regeneration, induction of liver fibrosis and subsequent cirrhosis often precedes hepatocarcinogenesis. The liver is a central immunomodulator that ensures organ and systemic protection while maintaining immunotolerance. Deregulation of this tightly controlled liver immunological network is a hallmark of chronic liver disease and HCC. Notably, immunotherapies have raised hope for the successful treatment of advanced HCC. Here we summarize the roles of specific immune cell subsets in chronic liver disease, with a focus on non-alcoholic steatohepatitis and HCC. We review new advances in immunotherapeutic approaches for the treatment of HCC and discuss the challenges posed by the immunotolerant hepatic environment and the dual roles of adaptive and innate immune cells in HCC.
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            MiRNA Biogenesis and Regulation of Diseases: An Overview.

            Anchal Vishnoi, Sweta Rani (2017)
            MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs holds huge potential for diagnostic and prognostic biomarkers, and as predictors of drug response.
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              Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.

              Ling Zhang, Zhen-Guang Wang, Yuan Yang … (2018)
              In recent years, circular RNAs (circRNAs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) remain largely unknown.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Bioengineered
                Journal ID (iso-abbrev): Bioengineered
                Title: Bioengineered
                Publisher: Taylor & Francis
                ISSN (Print): 2165-5979
                ISSN (Electronic): 2165-5987
                Publication date (Electronic, pub): 26 January 2022
                Publication date (Electronic, collection): 2022
                Publication date PMC-release: 26 January 2022
                Volume: 13
                Issue: 2
                Pages: 3666-3679
                Affiliations
                [a ]Department of Orthopedics, Dalian Municipal Central Hospital Affiliated of Dalian Medical University; , Dalian City, Liaoning Province, PR. China
                [b ]Department of Gastroenterology& Hepatology, First Affiliated Hospital of Dalian Medical University; , Dalian City, Liaoning Province, PR. China
                Author notes
                CONTACT Xiaoling Geng xiaolinggengdalian@ 123456163.com Department of Gastroenterology& Hepatology, First Affiliated Hospital of Dalian Medical University; , No. 222 Zhongshan Road, Dalian City, Liaoning Province 116000, PR. China
                Author information
                https://orcid.org/0000-0002-6854-6902
                Article
                Publisher ID: 2024328
                DOI: 10.1080/21655979.2021.2024328
                PMC ID: 8974008
                PubMed ID: 35081873
                SO-VID: 17cbd749-317d-4dae-8f4e-24f110b89e0e
                Copyright © © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 7, References: 53, Pages: 14
                Categories
                Subject: Research Article
                Subject: Research Paper

                ScienceOpen disciplines: Biomedical engineering
                Keywords: lncrna cytor,hepatocellular carcinoma,mir-125a-5p,lasp1,proliferation,apoptosis
                Data availability:
                ScienceOpen disciplines: Biomedical engineering
                Keywords: lncrna cytor, hepatocellular carcinoma, mir-125a-5p, lasp1, proliferation, apoptosis

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