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      Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages

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          Abstract

          Single doses of drugs active aginst Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearence of the blood parasites in experimentally infected mice. Furthermore, the in vitro phagocytosis and intracellular destruction by mouse peritoneal macrophage of blood forms collected from the treatment animals is strongly enhanced as compared with parasites from untreated controls. The uptake of the blood forms by macrophages is significantly higher with megazol than with benznidazole and nifurtimox, a finding that concurs with data showing that megazol is also the most active compound in the living host. The possibility that macrophages participate in a synergic effect between the host immune response and chemotherapeutic effect is discussed.

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          Author and article information

          Journal
          mioc
          Memórias do Instituto Oswaldo Cruz
          Mem. Inst. Oswaldo Cruz
          Instituto Oswaldo Cruz, Ministério da Saúde (Rio de Janeiro, RJ, Brazil )
          0074-0276
          1678-8060
          December 1990
          : 85
          : 4
          : 401-405
          Affiliations
          [01] Uberaba orgnameFaculdade de Medicina do Triângulo Mineiro Brasil
          [02] Belo Horizonte orgnameFIOCRUZ orgdiv1Centro de Pesquisas René Rachou Brasil
          Article
          S0074-02761990000400003 S0074-0276(90)08500403
          10.1590/S0074-02761990000400003
          17a13ffa-75a6-45a3-aff7-19070fb4f9d7

          This work is licensed under a Creative Commons Attribution 4.0 International License.

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          Figures: 0, Tables: 0, Equations: 0, References: 0, Pages: 5
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          SciELO Brazil


          host treatment,phagocytosis,mouse,macrophages,Trypanosoma cruzi

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