Ashley L. Comer:
ORCID: http://orcid.org/0000-0002-7073-892X
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – original draftRole: Writing – review & editing
Tushare Jinadasa:
ORCID: http://orcid.org/0000-0002-2693-9951
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – review & editing
Balaji Sriram:
ORCID: http://orcid.org/0000-0002-9550-3190
Role: Formal analysisRole: Methodology
Rhushikesh A. Phadke: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Lisa N. Kretsge: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Thanh P. H. Nguyen:
ORCID: http://orcid.org/0000-0002-6177-5323
Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Giovanna Antognetti: Role: Resources
James P. Gilbert:
ORCID: http://orcid.org/0000-0002-0947-4654
Role: Resources
Jungjoon Lee: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Elena R. Newmark:
ORCID: http://orcid.org/0000-0003-3250-4126
Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Frances S. Hausmann:
ORCID: http://orcid.org/0000-0001-5867-6642
Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
SaraAnn Rosenthal: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Kevin Liu Kot:
ORCID: http://orcid.org/0000-0002-8019-4911
Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Yenyu Liu: Role: Formal analysisRole: Methodology
William W. Yen:
ORCID: http://orcid.org/0000-0002-3536-3122
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administration
Borislav Dejanovic: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – review & editing
Alberto Cruz-Martín:
ORCID: http://orcid.org/0000-0002-3271-7220
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: Writing – original draftRole: Writing – review & editing
Eric J. Nestler: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
14
January
2020
Publication date Collection:
January
2020
Publication date PMC-release: 14
January
2020
Volume: 18
Issue: 1
Electronic Location Identifier: e3000604
Affiliations
[1
]
Department of Biology, Boston University, Boston, Massachusetts, United States of
America
[2
]
The Graduate Program for Neuroscience, Boston University, Boston, Massachusetts, United
States of America
[3
]
Neurophotonics Center, Boston University, Boston, Massachusetts, United States of
America
[4
]
Research and Early Development, Biogen, Cambridge, Massachusetts, United States of
America
[5
]
Molecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston,
Massachusetts, United States of America
[6
]
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United
States of America
[7
]
Biologics Drug Discovery, Biogen, Cambridge, Massachusetts, United States of America
[8
]
External Innovations and New Indications, Biogen, Cambridge, Massachusetts, United
States of America
[9
]
Department of Biology, Connecticut College, New London, Connecticut, United States
of America
[10
]
Biochemistry and Molecular Biology/Biotechnology Program, Boston University, Boston,
Massachusetts, United States of America
[11
]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge,
Massachusetts, United States of America
[12
]
Department Pharmacology and Experimental Therapeutics, Boston University, Boston,
Massachusetts, United States of America
[13
]
Center for Systems Neuroscience, Boston University, Boston, Massachusetts, United
States of America
Mount Sinai School of Medicine, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PBIOLOGY-D-19-01099
DOI: 10.1371/journal.pbio.3000604
PMC ID: 6959572
PubMed ID: 31935214
SO-VID: 179aafb9-0ac1-4ca8-b9dd-792fbb2d1d89
Copyright © © 2020 Comer et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Brain and Behavior Research Foundation
Award ID: 27202
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3271-7220
Alberto Cruz-Martín
Funded by: NSF
Award ID: DGE-1633516
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7073-892X
Ashley L. Comer
Funded by: NSF
Award ID: DGE-1633516
Award Recipient
:
Lisa N. Kretsge
Funded by: Boston University Brenton R. Lutz Award
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7073-892X
Ashley L. Comer
Funded by: funder-id http://dx.doi.org/10.13039/100005614, Biogen;
Award ID: 973630
Award Recipient
:
ORCID: http://orcid.org/0000-0002-3271-7220
Alberto Cruz-Martín
This work was supported by Biogen (AC-M, #973630), a NARSAD Young Investigator Grant
(AC-M, #27202), the Brenton R. Lutz Award (ALC), the NSF NRT UtB: Neurophotonics National
Research Fellowship (ALC and LNK, #DGE-1633516), and the Boston University Undergraduate
Research Opportunities Program (JL, FSH, TPHN, KLK, ERN, WWY) (
https://www.biogen.com/en_us/home.html;
https://www.bbrfoundation.org/grants-prizes/grants,
https://www.nsf.gov/;
http://www.bu.edu/urop/). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Glial Cells
Subject:
Microglial Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Neuronal Dendrites
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Neuronal Dendrites
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Rodents
Subject:
Mice
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Lysosomes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Prefrontal Cortex
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Brain
Subject:
Prefrontal Cortex
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Gene Expression and Vector Techniques
Subject:
Hyperexpression Techniques
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Gene Expression and Vector Techniques
Subject:
Hyperexpression Techniques
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Luminescent Proteins
Subject:
Green Fluorescent Protein
