It has been proposed that tropical cyclogenesis rates can be expressed as the product of the frequency of “seeds” and a transition probability that depends on the large-scale environment. Here it is demonstrated that the partitioning between seed frequency and transition probability depends on the seed definition and that the existence of such a partition does not resolve the long-standing issue of whether tropical cyclone frequency is controlled more by environmental conditions or by the statistics of background weather. It is here argued that tropical cyclone climatology is mostly controlled by regional environment and that the response of global tropical cyclone activity to globally uniform radiative forcing may be more controlled by the regionality of the response than by the mean response.