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      Microglial phagocytosis of live neurons.

      Nature reviews. Neuroscience
      Animals, Cell Death, physiology, Humans, Microglia, cytology, Neurons, Phagocytosis

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          Abstract

          Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well as synapses and the processes of live neurons. However, we and others have recently shown that microglia can also execute neuronal death by phagocytosing stressed-but-viable neurons - a process that we have termed phagoptosis. In this Progress article, we discuss evidence suggesting that phagoptosis may contribute to neuronal loss during brain development, inflammation, ischaemia and neurodegeneration.

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          Author and article information

          Journal
          24646669
          10.1038/nrn3710

          Chemistry
          Animals,Cell Death,physiology,Humans,Microglia,cytology,Neurons,Phagocytosis
          Chemistry
          Animals, Cell Death, physiology, Humans, Microglia, cytology, Neurons, Phagocytosis

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