Tumor-derived CD4+CD25+regulatory T cells inhibit dendritic cells function by CTLA-4.

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Abstract

CD4+CD25+regulatoryT cells (Tregs) play an important role in anti-tumor immune responses. Poor prognosis and declining survival rates have intimate connection with high Treg expression in cancer patients. Cytotoxic T Lymphocyte-associated protein (CTLA-4) is one of the most prominent molecules on Treg. In our previous research, we have demonstrated that HCC-derived Tregs can interfere with Dendritic cells (DCs) function and down-modulate CD80/CD86 on DCs in vitro in a cell-contact dependent way. However the mechanism of how HCC-derived Treg affect DC phenotype are not very clear. Therefore, we investigated the function of CTLA-4 in anti-tumor immune responses.

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Author and article information

Journal

Journal ID (iso-abbrev): Pathol. Res. Pract.

Title: Pathology, research and practice

Publisher: Elsevier BV

ISSN (Electronic): 1618-0631

ISSN (Print): 0344-0338

Publication date (Electronic): Mar 2017

Volume: 213

Issue: 3

Affiliations

[1 ] Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.

[2 ] Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, ZheJiang, China.

[3 ] Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. Electronic address: 515359290@qq.com.

Article

Publisher Item ID: S0344-0338(16)30236-9

DOI: 10.1016/j.prp.2016.12.008

PubMed ID: 28214198

SO-VID: 16a1d762-4401-47f0-9ac0-e896b5588369

History

Keywords: CTLA-4,Dendritic cell,CD4+CD25+regulatory T cell

Data availability:

Keywords: CTLA-4, Dendritic cell, CD4+CD25+regulatory T cell

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